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A C1173T Dimorphism in the VKORC1 Gene Determines Coumarin Sensitivity and Bleeding Risk

BACKGROUND: A C1173T polymorphism in intron 1 of the VKORC1 gene has been claimed to determine the interindividual variability in the response to vitamin K antagonist therapy (VKA), but it is unknown whether it also influences bleeding risk. We aimed to confirm the relationship between C1173T status...

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Detalles Bibliográficos
Autores principales:	Reitsma, Pieter H, van der Heijden, Jeroen F., Groot, Angelique P, Rosendaal, Frits R, Büller, Harry R
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2005
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1251635/ https://www.ncbi.nlm.nih.gov/pubmed/16201835 http://dx.doi.org/10.1371/journal.pmed.0020312

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