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B lymphocytopenia in rheumatoid arthritis is associated with the DRB1 shared epitope and increased acute phase response
The influence of HLA DRB1 alleles on B-cell homeostasis was analyzed in 164 patients with rheumatoid arthritis (RA). The percentages of CD19(+) B lymphocytes determined in the peripheral circulation of 94 retrospectively recruited RA patients followed a bimodal distribution. Two frequency peaks (B-c...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2002
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC125293/ https://www.ncbi.nlm.nih.gov/pubmed/12106500 http://dx.doi.org/10.1186/ar420 |
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author | Wagner, Ulf Kaltenhäuser, Sylke Pierer, Matthias Wilke, Bernd Arnold, Sybille Häntzschel, Holm |
author_facet | Wagner, Ulf Kaltenhäuser, Sylke Pierer, Matthias Wilke, Bernd Arnold, Sybille Häntzschel, Holm |
author_sort | Wagner, Ulf |
collection | PubMed |
description | The influence of HLA DRB1 alleles on B-cell homeostasis was analyzed in 164 patients with rheumatoid arthritis (RA). The percentages of CD19(+) B lymphocytes determined in the peripheral circulation of 94 retrospectively recruited RA patients followed a bimodal distribution. Two frequency peaks (B-cell(low) patients and B-cell(high) patients) were separated by the population median of a B-cell frequency of 8.5% of all lymphocytes. Human leucocyte antigen genotyping revealed that the B-cell(low) patients were more frequently positive for the RA-associated HLA DRB1 shared epitope (SE) than were B-cell(high) patients. Accordingly, SE-positive patients had lower CD19 percentages in the rank-sum analysis when compared with SE-negative patients, and were markedly B lymphocytopenic when compared with a healthy control group. To confirm the differential frequencies of CD19(+) B cells, absolute numbers in peripheral blood were determined prospectively in a cohort of 70 RA patients with recent onset disease. SE-positive patients were found to have lower absolute numbers of circulating CD19(+) B cells. B-cell counts below the mean of the study population were associated with higher acute phase response and with increased levels of rheumatoid factor IgA. No correlation between absolute numbers of circulating B cells and radiographic progression of joint destruction was seen. The influence of immunogenetic parameters on B-cell homeostasis in RA reported here has not been described previously. The clinical relevance of B lymphocytopenia in SE-positive RA will be further investigated in longitudinal studies. |
format | Text |
id | pubmed-125293 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2002 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-1252932002-09-26 B lymphocytopenia in rheumatoid arthritis is associated with the DRB1 shared epitope and increased acute phase response Wagner, Ulf Kaltenhäuser, Sylke Pierer, Matthias Wilke, Bernd Arnold, Sybille Häntzschel, Holm Arthritis Res Research Article The influence of HLA DRB1 alleles on B-cell homeostasis was analyzed in 164 patients with rheumatoid arthritis (RA). The percentages of CD19(+) B lymphocytes determined in the peripheral circulation of 94 retrospectively recruited RA patients followed a bimodal distribution. Two frequency peaks (B-cell(low) patients and B-cell(high) patients) were separated by the population median of a B-cell frequency of 8.5% of all lymphocytes. Human leucocyte antigen genotyping revealed that the B-cell(low) patients were more frequently positive for the RA-associated HLA DRB1 shared epitope (SE) than were B-cell(high) patients. Accordingly, SE-positive patients had lower CD19 percentages in the rank-sum analysis when compared with SE-negative patients, and were markedly B lymphocytopenic when compared with a healthy control group. To confirm the differential frequencies of CD19(+) B cells, absolute numbers in peripheral blood were determined prospectively in a cohort of 70 RA patients with recent onset disease. SE-positive patients were found to have lower absolute numbers of circulating CD19(+) B cells. B-cell counts below the mean of the study population were associated with higher acute phase response and with increased levels of rheumatoid factor IgA. No correlation between absolute numbers of circulating B cells and radiographic progression of joint destruction was seen. The influence of immunogenetic parameters on B-cell homeostasis in RA reported here has not been described previously. The clinical relevance of B lymphocytopenia in SE-positive RA will be further investigated in longitudinal studies. BioMed Central 2002 2002-05-02 /pmc/articles/PMC125293/ /pubmed/12106500 http://dx.doi.org/10.1186/ar420 Text en Copyright © 2002 Wagner et al., licensee BioMed Central Ltd |
spellingShingle | Research Article Wagner, Ulf Kaltenhäuser, Sylke Pierer, Matthias Wilke, Bernd Arnold, Sybille Häntzschel, Holm B lymphocytopenia in rheumatoid arthritis is associated with the DRB1 shared epitope and increased acute phase response |
title | B lymphocytopenia in rheumatoid arthritis is associated with the DRB1 shared epitope and increased acute phase response |
title_full | B lymphocytopenia in rheumatoid arthritis is associated with the DRB1 shared epitope and increased acute phase response |
title_fullStr | B lymphocytopenia in rheumatoid arthritis is associated with the DRB1 shared epitope and increased acute phase response |
title_full_unstemmed | B lymphocytopenia in rheumatoid arthritis is associated with the DRB1 shared epitope and increased acute phase response |
title_short | B lymphocytopenia in rheumatoid arthritis is associated with the DRB1 shared epitope and increased acute phase response |
title_sort | b lymphocytopenia in rheumatoid arthritis is associated with the drb1 shared epitope and increased acute phase response |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC125293/ https://www.ncbi.nlm.nih.gov/pubmed/12106500 http://dx.doi.org/10.1186/ar420 |
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