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Plasma lipid profiles and risk of cardiovascular disease in occupational lead exposure in Abeokuta, Nigeria
In order to investigate the effects of lead exposure on risk of cardiovascular disease during occupational exposure to this metal, plasma cholesterol and its fractions as high-density liporotein (HDL), low-density liporotein (LDL) and triglyceride were determined in various artisans in Abeokuta, Nig...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2005
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253530/ https://www.ncbi.nlm.nih.gov/pubmed/16191200 http://dx.doi.org/10.1186/1476-511X-4-19 |
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author | Ademuyiwa, Oladipo Ugbaja, Regina Ngozi Idumebor, Florence Adebawo, Olugbenga |
author_facet | Ademuyiwa, Oladipo Ugbaja, Regina Ngozi Idumebor, Florence Adebawo, Olugbenga |
author_sort | Ademuyiwa, Oladipo |
collection | PubMed |
description | In order to investigate the effects of lead exposure on risk of cardiovascular disease during occupational exposure to this metal, plasma cholesterol and its fractions as high-density liporotein (HDL), low-density liporotein (LDL) and triglyceride were determined in various artisans in Abeokuta, Nigeria who have been shown to be occupationally exposed to lead and these were related to blood lead levels. Increased risk of cardiovascular disease was observed in the artisans. Total cholesterol in the artisans was between 1.5 and 2.0 times higher in the artisans than that present in controls while LDL cholesterol was between 1.6 and 2.4 times higher in the artisans when compared with control subjects [p < 0.001]. HDL cholesterol and triglyceride levels were not affected [p > 0.05]. A significant positive correlation was observed between blood lead and total cholesterol on one hand [r = 0.372; p = 3.0 × 10(-5)] and blood lead and LDL cholesterol on the other hand [r = 0.283; p = 0.001]. LDL/HDL cholesterol ratio was also higher in the artisans when compared with control. Blood pressure (systolic and diastolic) and other anthropometric parameters were not significantly different between the artisans and the control subjects [p > 0.05]. Results suggest that lead exposure increases cholesterol synthesis and transport to peripheral tissues whereas reverse cholesterol transport to the liver is not affected. |
format | Text |
id | pubmed-1253530 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-12535302005-10-13 Plasma lipid profiles and risk of cardiovascular disease in occupational lead exposure in Abeokuta, Nigeria Ademuyiwa, Oladipo Ugbaja, Regina Ngozi Idumebor, Florence Adebawo, Olugbenga Lipids Health Dis Research In order to investigate the effects of lead exposure on risk of cardiovascular disease during occupational exposure to this metal, plasma cholesterol and its fractions as high-density liporotein (HDL), low-density liporotein (LDL) and triglyceride were determined in various artisans in Abeokuta, Nigeria who have been shown to be occupationally exposed to lead and these were related to blood lead levels. Increased risk of cardiovascular disease was observed in the artisans. Total cholesterol in the artisans was between 1.5 and 2.0 times higher in the artisans than that present in controls while LDL cholesterol was between 1.6 and 2.4 times higher in the artisans when compared with control subjects [p < 0.001]. HDL cholesterol and triglyceride levels were not affected [p > 0.05]. A significant positive correlation was observed between blood lead and total cholesterol on one hand [r = 0.372; p = 3.0 × 10(-5)] and blood lead and LDL cholesterol on the other hand [r = 0.283; p = 0.001]. LDL/HDL cholesterol ratio was also higher in the artisans when compared with control. Blood pressure (systolic and diastolic) and other anthropometric parameters were not significantly different between the artisans and the control subjects [p > 0.05]. Results suggest that lead exposure increases cholesterol synthesis and transport to peripheral tissues whereas reverse cholesterol transport to the liver is not affected. BioMed Central 2005-09-28 /pmc/articles/PMC1253530/ /pubmed/16191200 http://dx.doi.org/10.1186/1476-511X-4-19 Text en Copyright © 2005 Ademuyiwa et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Ademuyiwa, Oladipo Ugbaja, Regina Ngozi Idumebor, Florence Adebawo, Olugbenga Plasma lipid profiles and risk of cardiovascular disease in occupational lead exposure in Abeokuta, Nigeria |
title | Plasma lipid profiles and risk of cardiovascular disease in occupational lead exposure in Abeokuta, Nigeria |
title_full | Plasma lipid profiles and risk of cardiovascular disease in occupational lead exposure in Abeokuta, Nigeria |
title_fullStr | Plasma lipid profiles and risk of cardiovascular disease in occupational lead exposure in Abeokuta, Nigeria |
title_full_unstemmed | Plasma lipid profiles and risk of cardiovascular disease in occupational lead exposure in Abeokuta, Nigeria |
title_short | Plasma lipid profiles and risk of cardiovascular disease in occupational lead exposure in Abeokuta, Nigeria |
title_sort | plasma lipid profiles and risk of cardiovascular disease in occupational lead exposure in abeokuta, nigeria |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253530/ https://www.ncbi.nlm.nih.gov/pubmed/16191200 http://dx.doi.org/10.1186/1476-511X-4-19 |
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