Effects of Loud Noise Exposure on DNA Integrity in Rat Adrenal Gland

Loud noise is generally considered an environmental stressor causing negative effects on acoustic, cardiovascular, nervous, and endocrine systems. In this study, we investigated the effects of noise exposure on DNA integrity in rat adrenal gland evaluated by the comet assay. The exposure to loud noi...

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Detalles Bibliográficos
Autores principales: Frenzilli, Giada, Lenzi, Paola, Scarcelli, Vittoria, Fornai, Francesco, Pellegrini, Antonio, Soldani, Paola, Paparelli, Antonio, Nigro, Marco
Formato: Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Science 2004
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253657/
https://www.ncbi.nlm.nih.gov/pubmed/15579411
http://dx.doi.org/10.1289/ehp.7249
Descripción
Sumario:Loud noise is generally considered an environmental stressor causing negative effects on acoustic, cardiovascular, nervous, and endocrine systems. In this study, we investigated the effects of noise exposure on DNA integrity in rat adrenal gland evaluated by the comet assay. The exposure to loud noise (100 dBA) for 12 hr caused a significant increase of DNA damage in the adrenal gland. Genetic alterations did not decrease 24 hr after the cessation of the stimulus. We hypothesize that an imbalance of redox cell status is responsible for the induction and persistence of noise-induced cellular damage.

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