Effects of Loud Noise Exposure on DNA Integrity in Rat Adrenal Gland

Loud noise is generally considered an environmental stressor causing negative effects on acoustic, cardiovascular, nervous, and endocrine systems. In this study, we investigated the effects of noise exposure on DNA integrity in rat adrenal gland evaluated by the comet assay. The exposure to loud noi...

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Autores principales: Frenzilli, Giada, Lenzi, Paola, Scarcelli, Vittoria, Fornai, Francesco, Pellegrini, Antonio, Soldani, Paola, Paparelli, Antonio, Nigro, Marco
Formato: Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Science 2004
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253657/
https://www.ncbi.nlm.nih.gov/pubmed/15579411
http://dx.doi.org/10.1289/ehp.7249
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author Frenzilli, Giada
Lenzi, Paola
Scarcelli, Vittoria
Fornai, Francesco
Pellegrini, Antonio
Soldani, Paola
Paparelli, Antonio
Nigro, Marco
author_facet Frenzilli, Giada
Lenzi, Paola
Scarcelli, Vittoria
Fornai, Francesco
Pellegrini, Antonio
Soldani, Paola
Paparelli, Antonio
Nigro, Marco
author_sort Frenzilli, Giada
collection PubMed
description Loud noise is generally considered an environmental stressor causing negative effects on acoustic, cardiovascular, nervous, and endocrine systems. In this study, we investigated the effects of noise exposure on DNA integrity in rat adrenal gland evaluated by the comet assay. The exposure to loud noise (100 dBA) for 12 hr caused a significant increase of DNA damage in the adrenal gland. Genetic alterations did not decrease 24 hr after the cessation of the stimulus. We hypothesize that an imbalance of redox cell status is responsible for the induction and persistence of noise-induced cellular damage.
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spelling pubmed-12536572005-11-08 Effects of Loud Noise Exposure on DNA Integrity in Rat Adrenal Gland Frenzilli, Giada Lenzi, Paola Scarcelli, Vittoria Fornai, Francesco Pellegrini, Antonio Soldani, Paola Paparelli, Antonio Nigro, Marco Environ Health Perspect Research Loud noise is generally considered an environmental stressor causing negative effects on acoustic, cardiovascular, nervous, and endocrine systems. In this study, we investigated the effects of noise exposure on DNA integrity in rat adrenal gland evaluated by the comet assay. The exposure to loud noise (100 dBA) for 12 hr caused a significant increase of DNA damage in the adrenal gland. Genetic alterations did not decrease 24 hr after the cessation of the stimulus. We hypothesize that an imbalance of redox cell status is responsible for the induction and persistence of noise-induced cellular damage. National Institute of Environmental Health Science 2004-12 2004-09-22 /pmc/articles/PMC1253657/ /pubmed/15579411 http://dx.doi.org/10.1289/ehp.7249 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright.
spellingShingle Research
Frenzilli, Giada
Lenzi, Paola
Scarcelli, Vittoria
Fornai, Francesco
Pellegrini, Antonio
Soldani, Paola
Paparelli, Antonio
Nigro, Marco
Effects of Loud Noise Exposure on DNA Integrity in Rat Adrenal Gland
title Effects of Loud Noise Exposure on DNA Integrity in Rat Adrenal Gland
title_full Effects of Loud Noise Exposure on DNA Integrity in Rat Adrenal Gland
title_fullStr Effects of Loud Noise Exposure on DNA Integrity in Rat Adrenal Gland
title_full_unstemmed Effects of Loud Noise Exposure on DNA Integrity in Rat Adrenal Gland
title_short Effects of Loud Noise Exposure on DNA Integrity in Rat Adrenal Gland
title_sort effects of loud noise exposure on dna integrity in rat adrenal gland
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253657/
https://www.ncbi.nlm.nih.gov/pubmed/15579411
http://dx.doi.org/10.1289/ehp.7249
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