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Occupational Exposure to Carbofuran and the Incidence of Cancer in the Agricultural Health Study
Carbofuran is a carbamate insecticide registered for use on a variety of food crops including corn, alfalfa, rice, and tobacco. An estimated 5 million pounds of carbofuran is used annually in the United States, and 45% of urban African-American women have detectable levels of carbofuran in their pla...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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National Institue of Environmental Health Sciences
2005
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253753/ https://www.ncbi.nlm.nih.gov/pubmed/15743716 http://dx.doi.org/10.1289/ehp.7451 |
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author | Bonner, Matthew R. Lee, Won Jin Sandler, Dale P. Hoppin, Jane A. Dosemeci, Mustafa Alavanja, Michael C. R. |
author_facet | Bonner, Matthew R. Lee, Won Jin Sandler, Dale P. Hoppin, Jane A. Dosemeci, Mustafa Alavanja, Michael C. R. |
author_sort | Bonner, Matthew R. |
collection | PubMed |
description | Carbofuran is a carbamate insecticide registered for use on a variety of food crops including corn, alfalfa, rice, and tobacco. An estimated 5 million pounds of carbofuran is used annually in the United States, and 45% of urban African-American women have detectable levels of carbofuran in their plasma. Nitrosated carbofuran has demonstrated mutagenic properties. We examined exposure to carbofuran and several tumor sites among 49,877 licensed pesticide applicators from Iowa and North Carolina enrolled in the Agricultural Health Study. We obtained information regarding years of use, frequency of use in an average year, and when use began for 22 pesticides using self-administered questionnaires. Poisson regression was used to calculate rate ratios (RR) and 95% confidence intervals (CIs) adjusting for potential confounders. Lung cancer risk was 3-fold higher for those with > 109 days of lifetime exposure to carbofuran (RR = 3.05; 95% CI, 0.94–9.87) compared with those with < 9 lifetime exposure days, with a significant dose–response trend for both days of use per year and total years of use. However, carbofuran use was not associated with lung cancer risk when nonexposed persons were used as the referent. In addition, carbofuran exposure was not associated with any other cancer site examined. Although carbamate pesticides are suspected human carcinogens, these results should be interpreted cautiously because there was no a priori hypothesis specifically linking carbofuran to lung cancer. |
format | Text |
id | pubmed-1253753 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | National Institue of Environmental Health Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-12537532005-11-08 Occupational Exposure to Carbofuran and the Incidence of Cancer in the Agricultural Health Study Bonner, Matthew R. Lee, Won Jin Sandler, Dale P. Hoppin, Jane A. Dosemeci, Mustafa Alavanja, Michael C. R. Environ Health Perspect Research Carbofuran is a carbamate insecticide registered for use on a variety of food crops including corn, alfalfa, rice, and tobacco. An estimated 5 million pounds of carbofuran is used annually in the United States, and 45% of urban African-American women have detectable levels of carbofuran in their plasma. Nitrosated carbofuran has demonstrated mutagenic properties. We examined exposure to carbofuran and several tumor sites among 49,877 licensed pesticide applicators from Iowa and North Carolina enrolled in the Agricultural Health Study. We obtained information regarding years of use, frequency of use in an average year, and when use began for 22 pesticides using self-administered questionnaires. Poisson regression was used to calculate rate ratios (RR) and 95% confidence intervals (CIs) adjusting for potential confounders. Lung cancer risk was 3-fold higher for those with > 109 days of lifetime exposure to carbofuran (RR = 3.05; 95% CI, 0.94–9.87) compared with those with < 9 lifetime exposure days, with a significant dose–response trend for both days of use per year and total years of use. However, carbofuran use was not associated with lung cancer risk when nonexposed persons were used as the referent. In addition, carbofuran exposure was not associated with any other cancer site examined. Although carbamate pesticides are suspected human carcinogens, these results should be interpreted cautiously because there was no a priori hypothesis specifically linking carbofuran to lung cancer. National Institue of Environmental Health Sciences 2005-03 2004-12-02 /pmc/articles/PMC1253753/ /pubmed/15743716 http://dx.doi.org/10.1289/ehp.7451 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
spellingShingle | Research Bonner, Matthew R. Lee, Won Jin Sandler, Dale P. Hoppin, Jane A. Dosemeci, Mustafa Alavanja, Michael C. R. Occupational Exposure to Carbofuran and the Incidence of Cancer in the Agricultural Health Study |
title | Occupational Exposure to Carbofuran and the Incidence of Cancer in the Agricultural Health Study |
title_full | Occupational Exposure to Carbofuran and the Incidence of Cancer in the Agricultural Health Study |
title_fullStr | Occupational Exposure to Carbofuran and the Incidence of Cancer in the Agricultural Health Study |
title_full_unstemmed | Occupational Exposure to Carbofuran and the Incidence of Cancer in the Agricultural Health Study |
title_short | Occupational Exposure to Carbofuran and the Incidence of Cancer in the Agricultural Health Study |
title_sort | occupational exposure to carbofuran and the incidence of cancer in the agricultural health study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253753/ https://www.ncbi.nlm.nih.gov/pubmed/15743716 http://dx.doi.org/10.1289/ehp.7451 |
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