Androgen conversion in osteoarthritis and rheumatoid arthritis synoviocytes – androstenedione and testosterone inhibit estrogen formation and favor production of more potent 5α-reduced androgens

In synovial cells of patients with osteoarthritis (OA) and rheumatoid arthritis (RA), conversion products of major anti-inflammatory androgens are as yet unknown but may be proinflammatory. Therefore, therapy with androgens in RA could be a problem. This study was carried out in order to compare con...

Descripción completa

Detalles Bibliográficos
Autores principales: Schmidt, Martin, Weidler, Claudia, Naumann, Heidrun, Anders, Sven, Schölmerich, Jürgen, Straub, Rainer H
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1257423/
https://www.ncbi.nlm.nih.gov/pubmed/16207335
http://dx.doi.org/10.1186/ar1769

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1257423/
https://www.ncbi.nlm.nih.gov/pubmed/16207335
http://dx.doi.org/10.1186/ar1769

Ejemplares similares