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Altered dendritic cell distribution in patients with common variable immunodeficiency

Recent data suggest a critical role for dendritic cells (DCs) in the generation of immunoglobulin-secreting plasma cells. In the work reported herein, we analyzed the frequency of peripheral blood plasmacytoid DCs (pDCs) and myeloid DCs (mDCs) in a cohort of 44 adults with common variable immunodefi...

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Autores principales: Viallard, Jean-François, Camou, Fabrice, André, Marc, Liferman, François, Moreau, Jean-François, Pellegrin, Jean-Luc, Blanco, Patrick
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1257427/
https://www.ncbi.nlm.nih.gov/pubmed/16207321
http://dx.doi.org/10.1186/ar1774
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author Viallard, Jean-François
Camou, Fabrice
André, Marc
Liferman, François
Moreau, Jean-François
Pellegrin, Jean-Luc
Blanco, Patrick
author_facet Viallard, Jean-François
Camou, Fabrice
André, Marc
Liferman, François
Moreau, Jean-François
Pellegrin, Jean-Luc
Blanco, Patrick
author_sort Viallard, Jean-François
collection PubMed
description Recent data suggest a critical role for dendritic cells (DCs) in the generation of immunoglobulin-secreting plasma cells. In the work reported herein, we analyzed the frequency of peripheral blood plasmacytoid DCs (pDCs) and myeloid DCs (mDCs) in a cohort of 44 adults with common variable immunodeficiency (CVID) classified according to their CD27 membrane expression status on B cells. A deep alteration in the distribution of DC subsets, especially of pDCs, in the peripheral blood of CVID patients was found. Patients with a reduced number of class-switched CD27(+)IgD(-)IgM(- )memory B cells and patients with granulomatous disease had a dramatic decrease in pDCs (P = 0.00005 and 0.0003 vs controls, respectively) and, to a lesser extent, of mDCs (P = 0.001 and 0.01 vs controls, respectively). In contrast, patients with normal numbers of switched memory B cells had a DC distribution pattern similar to that in controls. Taken together, our results raise the possibility that innate immunity contributes to pathogenesis in CVID.
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spelling pubmed-12574272005-10-19 Altered dendritic cell distribution in patients with common variable immunodeficiency Viallard, Jean-François Camou, Fabrice André, Marc Liferman, François Moreau, Jean-François Pellegrin, Jean-Luc Blanco, Patrick Arthritis Res Ther Research Article Recent data suggest a critical role for dendritic cells (DCs) in the generation of immunoglobulin-secreting plasma cells. In the work reported herein, we analyzed the frequency of peripheral blood plasmacytoid DCs (pDCs) and myeloid DCs (mDCs) in a cohort of 44 adults with common variable immunodeficiency (CVID) classified according to their CD27 membrane expression status on B cells. A deep alteration in the distribution of DC subsets, especially of pDCs, in the peripheral blood of CVID patients was found. Patients with a reduced number of class-switched CD27(+)IgD(-)IgM(- )memory B cells and patients with granulomatous disease had a dramatic decrease in pDCs (P = 0.00005 and 0.0003 vs controls, respectively) and, to a lesser extent, of mDCs (P = 0.001 and 0.01 vs controls, respectively). In contrast, patients with normal numbers of switched memory B cells had a DC distribution pattern similar to that in controls. Taken together, our results raise the possibility that innate immunity contributes to pathogenesis in CVID. BioMed Central 2005 2005-07-01 /pmc/articles/PMC1257427/ /pubmed/16207321 http://dx.doi.org/10.1186/ar1774 Text en Copyright © 2005 Viallard et al.; licensee BioMed Central Ltd.
spellingShingle Research Article
Viallard, Jean-François
Camou, Fabrice
André, Marc
Liferman, François
Moreau, Jean-François
Pellegrin, Jean-Luc
Blanco, Patrick
Altered dendritic cell distribution in patients with common variable immunodeficiency
title Altered dendritic cell distribution in patients with common variable immunodeficiency
title_full Altered dendritic cell distribution in patients with common variable immunodeficiency
title_fullStr Altered dendritic cell distribution in patients with common variable immunodeficiency
title_full_unstemmed Altered dendritic cell distribution in patients with common variable immunodeficiency
title_short Altered dendritic cell distribution in patients with common variable immunodeficiency
title_sort altered dendritic cell distribution in patients with common variable immunodeficiency
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1257427/
https://www.ncbi.nlm.nih.gov/pubmed/16207321
http://dx.doi.org/10.1186/ar1774
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