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Molecular mechanisms of autoimmunity triggered by microbial infection

Autoimmunity can be triggered by microbial infection. In this context, the discovery of Toll-like receptors (TLRs) provides new insights and research perspectives. TLRs induce innate and adaptive antimicrobial immune responses upon exposure to common pathogen-associated molecules, including lipopept...

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Detalles Bibliográficos
Autores principales: Anders, Hans-Joachim, Zecher, Daniel, Pawar, Rahul D, Patole, Prashant S
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1257453/
https://www.ncbi.nlm.nih.gov/pubmed/16207351
http://dx.doi.org/10.1186/ar1818
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author Anders, Hans-Joachim
Zecher, Daniel
Pawar, Rahul D
Patole, Prashant S
author_facet Anders, Hans-Joachim
Zecher, Daniel
Pawar, Rahul D
Patole, Prashant S
author_sort Anders, Hans-Joachim
collection PubMed
description Autoimmunity can be triggered by microbial infection. In this context, the discovery of Toll-like receptors (TLRs) provides new insights and research perspectives. TLRs induce innate and adaptive antimicrobial immune responses upon exposure to common pathogen-associated molecules, including lipopeptides, lipopolysaccharides, and nucleic acids. They also have the potential, however, to trigger autoimmune disease, as has been revealed by an increasing number of experimental reports. This review summarizes important facts about TLR biology, available data on their role in autoimmunity, and potential consequences for the management of patients with autoimmune disease.
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spelling pubmed-12574532005-10-19 Molecular mechanisms of autoimmunity triggered by microbial infection Anders, Hans-Joachim Zecher, Daniel Pawar, Rahul D Patole, Prashant S Arthritis Res Ther Review Autoimmunity can be triggered by microbial infection. In this context, the discovery of Toll-like receptors (TLRs) provides new insights and research perspectives. TLRs induce innate and adaptive antimicrobial immune responses upon exposure to common pathogen-associated molecules, including lipopeptides, lipopolysaccharides, and nucleic acids. They also have the potential, however, to trigger autoimmune disease, as has been revealed by an increasing number of experimental reports. This review summarizes important facts about TLR biology, available data on their role in autoimmunity, and potential consequences for the management of patients with autoimmune disease. BioMed Central 2005 2005-08-30 /pmc/articles/PMC1257453/ /pubmed/16207351 http://dx.doi.org/10.1186/ar1818 Text en Copyright © 2005 BioMed Central Ltd
spellingShingle Review
Anders, Hans-Joachim
Zecher, Daniel
Pawar, Rahul D
Patole, Prashant S
Molecular mechanisms of autoimmunity triggered by microbial infection
title Molecular mechanisms of autoimmunity triggered by microbial infection
title_full Molecular mechanisms of autoimmunity triggered by microbial infection
title_fullStr Molecular mechanisms of autoimmunity triggered by microbial infection
title_full_unstemmed Molecular mechanisms of autoimmunity triggered by microbial infection
title_short Molecular mechanisms of autoimmunity triggered by microbial infection
title_sort molecular mechanisms of autoimmunity triggered by microbial infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1257453/
https://www.ncbi.nlm.nih.gov/pubmed/16207351
http://dx.doi.org/10.1186/ar1818
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