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Molecular mechanisms of autoimmunity triggered by microbial infection
Autoimmunity can be triggered by microbial infection. In this context, the discovery of Toll-like receptors (TLRs) provides new insights and research perspectives. TLRs induce innate and adaptive antimicrobial immune responses upon exposure to common pathogen-associated molecules, including lipopept...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2005
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1257453/ https://www.ncbi.nlm.nih.gov/pubmed/16207351 http://dx.doi.org/10.1186/ar1818 |
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author | Anders, Hans-Joachim Zecher, Daniel Pawar, Rahul D Patole, Prashant S |
author_facet | Anders, Hans-Joachim Zecher, Daniel Pawar, Rahul D Patole, Prashant S |
author_sort | Anders, Hans-Joachim |
collection | PubMed |
description | Autoimmunity can be triggered by microbial infection. In this context, the discovery of Toll-like receptors (TLRs) provides new insights and research perspectives. TLRs induce innate and adaptive antimicrobial immune responses upon exposure to common pathogen-associated molecules, including lipopeptides, lipopolysaccharides, and nucleic acids. They also have the potential, however, to trigger autoimmune disease, as has been revealed by an increasing number of experimental reports. This review summarizes important facts about TLR biology, available data on their role in autoimmunity, and potential consequences for the management of patients with autoimmune disease. |
format | Text |
id | pubmed-1257453 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-12574532005-10-19 Molecular mechanisms of autoimmunity triggered by microbial infection Anders, Hans-Joachim Zecher, Daniel Pawar, Rahul D Patole, Prashant S Arthritis Res Ther Review Autoimmunity can be triggered by microbial infection. In this context, the discovery of Toll-like receptors (TLRs) provides new insights and research perspectives. TLRs induce innate and adaptive antimicrobial immune responses upon exposure to common pathogen-associated molecules, including lipopeptides, lipopolysaccharides, and nucleic acids. They also have the potential, however, to trigger autoimmune disease, as has been revealed by an increasing number of experimental reports. This review summarizes important facts about TLR biology, available data on their role in autoimmunity, and potential consequences for the management of patients with autoimmune disease. BioMed Central 2005 2005-08-30 /pmc/articles/PMC1257453/ /pubmed/16207351 http://dx.doi.org/10.1186/ar1818 Text en Copyright © 2005 BioMed Central Ltd |
spellingShingle | Review Anders, Hans-Joachim Zecher, Daniel Pawar, Rahul D Patole, Prashant S Molecular mechanisms of autoimmunity triggered by microbial infection |
title | Molecular mechanisms of autoimmunity triggered by microbial infection |
title_full | Molecular mechanisms of autoimmunity triggered by microbial infection |
title_fullStr | Molecular mechanisms of autoimmunity triggered by microbial infection |
title_full_unstemmed | Molecular mechanisms of autoimmunity triggered by microbial infection |
title_short | Molecular mechanisms of autoimmunity triggered by microbial infection |
title_sort | molecular mechanisms of autoimmunity triggered by microbial infection |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1257453/ https://www.ncbi.nlm.nih.gov/pubmed/16207351 http://dx.doi.org/10.1186/ar1818 |
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