In Vitro Inhibition of Human Hepatic and cDNA-Expressed Sulfotransferase Activity with 3-Hydroxybenzo[a]pyrene by Polychlorobiphenylols

Sulfonation is a major phase II biotransformation reaction. In this study, we found that several polychlorobiphenylols (OH-PCBs) inhibited the sulfonation of 3-hydroxybenzo[a]pyrene (3-OH-BaP) by human liver cytosol and some cDNA-expressed sulfotransferases. At concentrations > 0.15 μM, 3-OH-BaP...

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Detalles Bibliográficos
Autores principales: Wang, Li-Quan, Lehmler, Hans-Joachim, Robertson, Larry W., Falany, Charles N., James, Margaret O.
Formato: Texto
Lenguaje:English
Publicado: National Institue of Environmental Health Sciences 2005
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1257591/
https://www.ncbi.nlm.nih.gov/pubmed/15929889
http://dx.doi.org/10.1289/ehp.7837

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1257591/
https://www.ncbi.nlm.nih.gov/pubmed/15929889
http://dx.doi.org/10.1289/ehp.7837

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