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Conformation, protein recognition and repair of DNA interstrand and intrastrand cross-links of Antitumor trans-[PtCl(2)(NH(3))(thiazole)]

Replacement of one ammine in clinically ineffective trans-[PtCl(2)(NH(3))(2)] (transplatin) by a planar N-heterocycle, thiazole, results in significantly enhanced cytotoxicity. Unlike ‘classical’ cisplatin {cis-[PtCl(2)(NH(3))(2)]} or transplatin, modification of DNA by this prototypical cytotoxic t...

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Detalles Bibliográficos
Autores principales:	Marini, Victoria, Christofis, Petros, Novakova, Olga, Kasparkova, Jana, Farrell, Nicholas, Brabec, Viktor
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2005
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1258167/ https://www.ncbi.nlm.nih.gov/pubmed/16237123 http://dx.doi.org/10.1093/nar/gki884

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