Comparison of Mycobacterium tuberculosis isocitrate dehydrogenases (ICD-1 and ICD-2) reveals differences in coenzyme affinity, oligomeric state, pH tolerance and phylogenetic affiliation

BACKGROUND: M.tb icd-1 and M.tb icd-2, have been identified in the Mycobacterium tuberculosis genome as probable isocitrate dehydrogenase (ICD) genes. Earlier we demonstrated that the two isoforms can elicit B cell response in TB patients and significantly differentiate TB infected population from h...

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Detalles Bibliográficos
Autores principales: Banerjee, Sharmistha, Nandyala, Ashok, Podili, RaviPrasad, Katoch, Vishwa Mohan, Hasnain, Seyed E
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1260013/
https://www.ncbi.nlm.nih.gov/pubmed/16194279
http://dx.doi.org/10.1186/1471-2091-6-20

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