JTT-130, a microsomal triglyceride transfer protein (MTP) inhibitor lowers plasma triglycerides and LDL cholesterol concentrations without increasing hepatic triglycerides in guinea pigs

BACKGROUND: Microsomal transfer protein inhibitors (MTPi) have the potential to be used as a drug to lower plasma lipids, mainly plasma triglycerides (TG). However, studies with animal models have indicated that MTPi treatment results in the accumulation of hepatic TG. The purpose of this study was...

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Detalles Bibliográficos
Autores principales: Aggarwal, Dimple, West, Kristy L, Zern, Tosca L, Shrestha, Sudeep, Vergara-Jimenez, Marcela, Fernandez, Maria Luz
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1262701/
https://www.ncbi.nlm.nih.gov/pubmed/16188040
http://dx.doi.org/10.1186/1471-2261-5-30

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