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Telomerase expression is sufficient for chromosomal integrity in cells lacking p53 dependent G(1 )checkpoint function

BACKGROUND: Secondary cultures of human fibroblasts display a finite lifespan ending at senescence. Loss of p53 function by mutation or viral oncogene expression bypasses senescence, allowing cell division to continue for an additional 10 – 20 doublings. During this time chromosomal aberrations seen...

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Detalles Bibliográficos
Autores principales:	Simpson, Dennis A, Livanos, Elizabeth, Heffernan, Timothy P, Kaufmann, William K
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2005
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1262734/ https://www.ncbi.nlm.nih.gov/pubmed/16209708 http://dx.doi.org/10.1186/1477-3163-4-18

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