Pro-domain removal in ASP-2 and the cleavage of the amyloid precursor are influenced by pH

BACKGROUND: One of the signatures of Alzheimer's disease is the accumulation of aggregated amyloid protein, Aβ, in the brain. Aβ arises from cleavage of the Amyloid Precursor protein by β and γ secretases, which present attractive candidates for therapeutic targeting. Two β-secretase candidates...

Descripción completa

Detalles Bibliográficos
Autores principales: Sidera, Christina, Liu, Chibuu, Austen, Brian
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC126479/
https://www.ncbi.nlm.nih.gov/pubmed/12204094
http://dx.doi.org/10.1186/1471-2091-3-25

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC126479/
https://www.ncbi.nlm.nih.gov/pubmed/12204094
http://dx.doi.org/10.1186/1471-2091-3-25

Ejemplares similares