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Ultra-sensitive detection of prion protein fibrils by flow cytometry in blood from cattle affected with bovine spongiform encephalopathy

BACKGROUND: The definite diagnosis of prion diseases such as Creutzfeldt-Jakob disease (CJD) in humans or bovine spongiform encephalopathy (BSE) in cattle currently relies on the post mortem detection of the pathological form of the prion protein (PrP(Sc)) in brain tissue. Infectivity studies indica...

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Detalles Bibliográficos
Autores principales: Trieschmann, Lothar, Santos, Alexander Navarrete, Kaschig, Katja, Torkler, Sandra, Maas, Elke, Schätzl, Hermann, Böhm, Gerald
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1266054/
https://www.ncbi.nlm.nih.gov/pubmed/16202155
http://dx.doi.org/10.1186/1472-6750-5-26