Application of single molecule technology to rapidly map long DNA and study the conformation of stretched DNA

Herein we describe the first application of direct linear analysis (DLA) to the mapping of a bacterial artificial chromosome (BAC), specifically the 185.1 kb-long BAC 12M9. DLA is a single molecule mapping technology, based on microfluidic elongation and interrogation of individual DNA molecules, se...

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Detalles Bibliográficos
Autores principales: Phillips, Kevin M., Larson, Jonathan W., Yantz, Gregory R., D'Antoni, Christina M., Gallo, Michael V., Gillis, Kimberly A., Goncalves, Nuno M., Neely, Lori A., Gullans, Steven R., Gilmanshin, Rudolf
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1266062/
https://www.ncbi.nlm.nih.gov/pubmed/16243782
http://dx.doi.org/10.1093/nar/gki895

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