Molecular characterisation of the caprine (Capra hircus) lymphocyte function-associated antigen-1 alpha subunit-encoding cDNA

BACKGROUND: Lymphocyte function-associated antigen-1 (LFA-1, CD11a/CD18, alpha L beta 2) is required for many cellular adhesive interactions during the immune response. RESULTS: The Capra hircus CD11a-encoding cDNA was sequenced and compared with its human, murine, rat, bovine and ovine counterparts...

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Autores principales: Fett, Thomas, Zecchinon, Laurent LM, Baise, Etienne A, Desmecht, Daniel JM
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1266385/
https://www.ncbi.nlm.nih.gov/pubmed/16216116
http://dx.doi.org/10.1186/1746-6148-1-4
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author Fett, Thomas
Zecchinon, Laurent LM
Baise, Etienne A
Desmecht, Daniel JM
author_facet Fett, Thomas
Zecchinon, Laurent LM
Baise, Etienne A
Desmecht, Daniel JM
author_sort Fett, Thomas
collection PubMed
description BACKGROUND: Lymphocyte function-associated antigen-1 (LFA-1, CD11a/CD18, alpha L beta 2) is required for many cellular adhesive interactions during the immune response. RESULTS: The Capra hircus CD11a-encoding cDNA was sequenced and compared with its human, murine, rat, bovine and ovine counterparts. Despite some focal differences, it shares all the main characteristics of its known mammalian homologues. CONCLUSION: Therefore, along with the caprine CD18-encoding cDNA, which has been available for a few months, the sequence data revealed here will allow the Capra hircus LFA-1 expression in vitro as a tool to explore the specificities of inflammation in the caprine species.
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spelling pubmed-12663852006-11-24 Molecular characterisation of the caprine (Capra hircus) lymphocyte function-associated antigen-1 alpha subunit-encoding cDNA Fett, Thomas Zecchinon, Laurent LM Baise, Etienne A Desmecht, Daniel JM BMC Vet Res Research Article BACKGROUND: Lymphocyte function-associated antigen-1 (LFA-1, CD11a/CD18, alpha L beta 2) is required for many cellular adhesive interactions during the immune response. RESULTS: The Capra hircus CD11a-encoding cDNA was sequenced and compared with its human, murine, rat, bovine and ovine counterparts. Despite some focal differences, it shares all the main characteristics of its known mammalian homologues. CONCLUSION: Therefore, along with the caprine CD18-encoding cDNA, which has been available for a few months, the sequence data revealed here will allow the Capra hircus LFA-1 expression in vitro as a tool to explore the specificities of inflammation in the caprine species. BioMed Central 2005-10-10 /pmc/articles/PMC1266385/ /pubmed/16216116 http://dx.doi.org/10.1186/1746-6148-1-4 Text en Copyright © 2005 Fett et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Fett, Thomas
Zecchinon, Laurent LM
Baise, Etienne A
Desmecht, Daniel JM
Molecular characterisation of the caprine (Capra hircus) lymphocyte function-associated antigen-1 alpha subunit-encoding cDNA
title Molecular characterisation of the caprine (Capra hircus) lymphocyte function-associated antigen-1 alpha subunit-encoding cDNA
title_full Molecular characterisation of the caprine (Capra hircus) lymphocyte function-associated antigen-1 alpha subunit-encoding cDNA
title_fullStr Molecular characterisation of the caprine (Capra hircus) lymphocyte function-associated antigen-1 alpha subunit-encoding cDNA
title_full_unstemmed Molecular characterisation of the caprine (Capra hircus) lymphocyte function-associated antigen-1 alpha subunit-encoding cDNA
title_short Molecular characterisation of the caprine (Capra hircus) lymphocyte function-associated antigen-1 alpha subunit-encoding cDNA
title_sort molecular characterisation of the caprine (capra hircus) lymphocyte function-associated antigen-1 alpha subunit-encoding cdna
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1266385/
https://www.ncbi.nlm.nih.gov/pubmed/16216116
http://dx.doi.org/10.1186/1746-6148-1-4
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