Integration of the subarachnoid space and lymphatics: Is it time to embrace a new concept of cerebrospinal fluid absorption?

In most tissues and organs, the lymphatic circulation is responsible for the removal of interstitial protein and fluid but the parenchyma of the brain and spinal cord is devoid of lymphatic vessels. On the other hand, the literature is filled with qualitative and quantitative evidence supporting a l...

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Detalles Bibliográficos
Autores principales: Koh, Lena, Zakharov, Andrei, Johnston, Miles
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1266390/
https://www.ncbi.nlm.nih.gov/pubmed/16174293
http://dx.doi.org/10.1186/1743-8454-2-6
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author Koh, Lena
Zakharov, Andrei
Johnston, Miles
author_facet Koh, Lena
Zakharov, Andrei
Johnston, Miles
author_sort Koh, Lena
collection PubMed
description In most tissues and organs, the lymphatic circulation is responsible for the removal of interstitial protein and fluid but the parenchyma of the brain and spinal cord is devoid of lymphatic vessels. On the other hand, the literature is filled with qualitative and quantitative evidence supporting a lymphatic function in cerebrospinal fluid (CSF) absorption. The experimental data seems to warrant a re-examination of CSF dynamics and consideration of a new conceptual foundation on which to base our understanding of disorders of the CSF system. The objective of this paper is to review the key studies pertaining to the role of the lymphatic system in CSF absorption.
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spelling pubmed-12663902005-10-27 Integration of the subarachnoid space and lymphatics: Is it time to embrace a new concept of cerebrospinal fluid absorption? Koh, Lena Zakharov, Andrei Johnston, Miles Cerebrospinal Fluid Res Review In most tissues and organs, the lymphatic circulation is responsible for the removal of interstitial protein and fluid but the parenchyma of the brain and spinal cord is devoid of lymphatic vessels. On the other hand, the literature is filled with qualitative and quantitative evidence supporting a lymphatic function in cerebrospinal fluid (CSF) absorption. The experimental data seems to warrant a re-examination of CSF dynamics and consideration of a new conceptual foundation on which to base our understanding of disorders of the CSF system. The objective of this paper is to review the key studies pertaining to the role of the lymphatic system in CSF absorption. BioMed Central 2005-09-20 /pmc/articles/PMC1266390/ /pubmed/16174293 http://dx.doi.org/10.1186/1743-8454-2-6 Text en Copyright © 2005 Koh et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Koh, Lena
Zakharov, Andrei
Johnston, Miles
Integration of the subarachnoid space and lymphatics: Is it time to embrace a new concept of cerebrospinal fluid absorption?
title Integration of the subarachnoid space and lymphatics: Is it time to embrace a new concept of cerebrospinal fluid absorption?
title_full Integration of the subarachnoid space and lymphatics: Is it time to embrace a new concept of cerebrospinal fluid absorption?
title_fullStr Integration of the subarachnoid space and lymphatics: Is it time to embrace a new concept of cerebrospinal fluid absorption?
title_full_unstemmed Integration of the subarachnoid space and lymphatics: Is it time to embrace a new concept of cerebrospinal fluid absorption?
title_short Integration of the subarachnoid space and lymphatics: Is it time to embrace a new concept of cerebrospinal fluid absorption?
title_sort integration of the subarachnoid space and lymphatics: is it time to embrace a new concept of cerebrospinal fluid absorption?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1266390/
https://www.ncbi.nlm.nih.gov/pubmed/16174293
http://dx.doi.org/10.1186/1743-8454-2-6
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AT johnstonmiles integrationofthesubarachnoidspaceandlymphaticsisittimetoembraceanewconceptofcerebrospinalfluidabsorption

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