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Perspectives on Human Genetic Variation from the HapMap Project

The completion of the International HapMap Project marks the start of a new phase in human genetics. The aim of the project was to provide a resource that facilitates the design of efficient genome-wide association studies, through characterising patterns of genetic variation and linkage disequilibr...

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Detalles Bibliográficos
Autores principales: McVean, Gil, Spencer, Chris C. A, Chaix, Raphaelle
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1270010/
https://www.ncbi.nlm.nih.gov/pubmed/16254603
http://dx.doi.org/10.1371/journal.pgen.0010054
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author McVean, Gil
Spencer, Chris C. A
Chaix, Raphaelle
author_facet McVean, Gil
Spencer, Chris C. A
Chaix, Raphaelle
author_sort McVean, Gil
collection PubMed
description The completion of the International HapMap Project marks the start of a new phase in human genetics. The aim of the project was to provide a resource that facilitates the design of efficient genome-wide association studies, through characterising patterns of genetic variation and linkage disequilibrium in a sample of 270 individuals across four geographical populations. In total, over one million SNPs have been typed across these genomes, providing an unprecedented view of human genetic diversity. In this review we focus on what the HapMap project has taught us about the structure of human genetic variation and the fundamental molecular and evolutionary processes that shape it.
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spelling pubmed-12700102007-02-28 Perspectives on Human Genetic Variation from the HapMap Project McVean, Gil Spencer, Chris C. A Chaix, Raphaelle PLoS Genet Review The completion of the International HapMap Project marks the start of a new phase in human genetics. The aim of the project was to provide a resource that facilitates the design of efficient genome-wide association studies, through characterising patterns of genetic variation and linkage disequilibrium in a sample of 270 individuals across four geographical populations. In total, over one million SNPs have been typed across these genomes, providing an unprecedented view of human genetic diversity. In this review we focus on what the HapMap project has taught us about the structure of human genetic variation and the fundamental molecular and evolutionary processes that shape it. Public Library of Science 2005-10 2005-10-28 /pmc/articles/PMC1270010/ /pubmed/16254603 http://dx.doi.org/10.1371/journal.pgen.0010054 Text en Copyright: © 2005 McVean et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Review
McVean, Gil
Spencer, Chris C. A
Chaix, Raphaelle
Perspectives on Human Genetic Variation from the HapMap Project
title Perspectives on Human Genetic Variation from the HapMap Project
title_full Perspectives on Human Genetic Variation from the HapMap Project
title_fullStr Perspectives on Human Genetic Variation from the HapMap Project
title_full_unstemmed Perspectives on Human Genetic Variation from the HapMap Project
title_short Perspectives on Human Genetic Variation from the HapMap Project
title_sort perspectives on human genetic variation from the hapmap project
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1270010/
https://www.ncbi.nlm.nih.gov/pubmed/16254603
http://dx.doi.org/10.1371/journal.pgen.0010054
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