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The burden of diarrhoea, shigellosis, and cholera in North Jakarta, Indonesia: findings from 24 months surveillance
BACKGROUND: In preparation of vaccines trials to estimate protection against shigellosis and cholera we conducted a two-year community-based surveillance study in an impoverished area of North Jakarta which provided updated information on the disease burden in the area. METHODS: We conducted a two-y...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2005
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1276796/ https://www.ncbi.nlm.nih.gov/pubmed/16242013 http://dx.doi.org/10.1186/1471-2334-5-89 |
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author | Agtini, Magdarina D Soeharno, Rooswanti Lesmana, Murad Punjabi, Narain H Simanjuntak, Cyrus Wangsasaputra, Ferry Nurdin, Dazwir Pulungsih, Sri Pandam Rofiq, Ainur Santoso, Hari Pujarwoto, H Sjahrurachman, Agus Sudarmono, Pratiwi von Seidlein, Lorenz Deen, Jacqueline L Ali, Mohammad Lee, Hyejon Kim, Deok Ryun Han, Oakpil Park, Jin Kyung Suwandono, Agus Ingerani Oyofo, Buhari A Campbell, James R Beecham, H James Corwin, Andrew L Clemens, John D |
author_facet | Agtini, Magdarina D Soeharno, Rooswanti Lesmana, Murad Punjabi, Narain H Simanjuntak, Cyrus Wangsasaputra, Ferry Nurdin, Dazwir Pulungsih, Sri Pandam Rofiq, Ainur Santoso, Hari Pujarwoto, H Sjahrurachman, Agus Sudarmono, Pratiwi von Seidlein, Lorenz Deen, Jacqueline L Ali, Mohammad Lee, Hyejon Kim, Deok Ryun Han, Oakpil Park, Jin Kyung Suwandono, Agus Ingerani Oyofo, Buhari A Campbell, James R Beecham, H James Corwin, Andrew L Clemens, John D |
author_sort | Agtini, Magdarina D |
collection | PubMed |
description | BACKGROUND: In preparation of vaccines trials to estimate protection against shigellosis and cholera we conducted a two-year community-based surveillance study in an impoverished area of North Jakarta which provided updated information on the disease burden in the area. METHODS: We conducted a two-year community-based surveillance study from August 2001 to July 2003 in an impoverished area of North Jakarta to assess the burden of diarrhoea, shigellosis, and cholera. At participating health care providers, a case report form was completed and stool sample collected from cases presenting with diarrhoea. RESULTS: Infants had the highest incidences of diarrhoea (759/1 000/year) and cholera (4/1 000/year). Diarrhea incidence was significantly higher in boys under 5 years (387/1 000/year) than girls under 5 years (309/1 000/year; p < 0.001). Children aged 1 to 2 years had the highest incidence of shigellosis (32/1 000/year). Shigella flexneri was the most common Shigella species isolated and 73% to 95% of these isolates were resistant to ampicillin, trimethoprim-sulfamethoxazole, chloramphenicol and tetracycline but remain susceptible to nalidixic acid, ciprofloxacin, and ceftriaxone. We found an overall incidence of cholera of 0.5/1 000/year. Cholera was most common in children, with the highest incidence at 4/1 000/year in those less than 1 year of age. Of the 154 V. cholerae O1 isolates, 89 (58%) were of the El Tor Ogawa serotype and 65 (42%) were El Tor Inaba. Thirty-four percent of patients with cholera were intravenously rehydrated and 22% required hospitalization. V. parahaemolyticus infections were detected sporadically but increased from July 2002 onwards. CONCLUSION: Diarrhoea causes a heavy public health burden in Jakarta particularly in young children. The impact of shigellosis is exacerbated by the threat of antimicrobial resistance, whereas that of cholera is aggravated by its severe manifestations. |
format | Text |
id | pubmed-1276796 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-12767962005-11-03 The burden of diarrhoea, shigellosis, and cholera in North Jakarta, Indonesia: findings from 24 months surveillance Agtini, Magdarina D Soeharno, Rooswanti Lesmana, Murad Punjabi, Narain H Simanjuntak, Cyrus Wangsasaputra, Ferry Nurdin, Dazwir Pulungsih, Sri Pandam Rofiq, Ainur Santoso, Hari Pujarwoto, H Sjahrurachman, Agus Sudarmono, Pratiwi von Seidlein, Lorenz Deen, Jacqueline L Ali, Mohammad Lee, Hyejon Kim, Deok Ryun Han, Oakpil Park, Jin Kyung Suwandono, Agus Ingerani Oyofo, Buhari A Campbell, James R Beecham, H James Corwin, Andrew L Clemens, John D BMC Infect Dis Research Article BACKGROUND: In preparation of vaccines trials to estimate protection against shigellosis and cholera we conducted a two-year community-based surveillance study in an impoverished area of North Jakarta which provided updated information on the disease burden in the area. METHODS: We conducted a two-year community-based surveillance study from August 2001 to July 2003 in an impoverished area of North Jakarta to assess the burden of diarrhoea, shigellosis, and cholera. At participating health care providers, a case report form was completed and stool sample collected from cases presenting with diarrhoea. RESULTS: Infants had the highest incidences of diarrhoea (759/1 000/year) and cholera (4/1 000/year). Diarrhea incidence was significantly higher in boys under 5 years (387/1 000/year) than girls under 5 years (309/1 000/year; p < 0.001). Children aged 1 to 2 years had the highest incidence of shigellosis (32/1 000/year). Shigella flexneri was the most common Shigella species isolated and 73% to 95% of these isolates were resistant to ampicillin, trimethoprim-sulfamethoxazole, chloramphenicol and tetracycline but remain susceptible to nalidixic acid, ciprofloxacin, and ceftriaxone. We found an overall incidence of cholera of 0.5/1 000/year. Cholera was most common in children, with the highest incidence at 4/1 000/year in those less than 1 year of age. Of the 154 V. cholerae O1 isolates, 89 (58%) were of the El Tor Ogawa serotype and 65 (42%) were El Tor Inaba. Thirty-four percent of patients with cholera were intravenously rehydrated and 22% required hospitalization. V. parahaemolyticus infections were detected sporadically but increased from July 2002 onwards. CONCLUSION: Diarrhoea causes a heavy public health burden in Jakarta particularly in young children. The impact of shigellosis is exacerbated by the threat of antimicrobial resistance, whereas that of cholera is aggravated by its severe manifestations. BioMed Central 2005-10-20 /pmc/articles/PMC1276796/ /pubmed/16242013 http://dx.doi.org/10.1186/1471-2334-5-89 Text en Copyright © 2005 Agtini et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Agtini, Magdarina D Soeharno, Rooswanti Lesmana, Murad Punjabi, Narain H Simanjuntak, Cyrus Wangsasaputra, Ferry Nurdin, Dazwir Pulungsih, Sri Pandam Rofiq, Ainur Santoso, Hari Pujarwoto, H Sjahrurachman, Agus Sudarmono, Pratiwi von Seidlein, Lorenz Deen, Jacqueline L Ali, Mohammad Lee, Hyejon Kim, Deok Ryun Han, Oakpil Park, Jin Kyung Suwandono, Agus Ingerani Oyofo, Buhari A Campbell, James R Beecham, H James Corwin, Andrew L Clemens, John D The burden of diarrhoea, shigellosis, and cholera in North Jakarta, Indonesia: findings from 24 months surveillance |
title | The burden of diarrhoea, shigellosis, and cholera in North Jakarta, Indonesia: findings from 24 months surveillance |
title_full | The burden of diarrhoea, shigellosis, and cholera in North Jakarta, Indonesia: findings from 24 months surveillance |
title_fullStr | The burden of diarrhoea, shigellosis, and cholera in North Jakarta, Indonesia: findings from 24 months surveillance |
title_full_unstemmed | The burden of diarrhoea, shigellosis, and cholera in North Jakarta, Indonesia: findings from 24 months surveillance |
title_short | The burden of diarrhoea, shigellosis, and cholera in North Jakarta, Indonesia: findings from 24 months surveillance |
title_sort | burden of diarrhoea, shigellosis, and cholera in north jakarta, indonesia: findings from 24 months surveillance |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1276796/ https://www.ncbi.nlm.nih.gov/pubmed/16242013 http://dx.doi.org/10.1186/1471-2334-5-89 |
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