Cargando…

Discriminating Different Classes of Toxicants by Transcript Profiling

Male rats were treated with various model compounds or the appropriate vehicle controls. Most substances were either well-known hepatotoxicants or showed hepatotoxicity during preclinical testing. The aim of the present study was to determine if biological samples from rats treated with various comp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Steiner, Guido, Suter, Laura, Boess, Franziska, Gasser, Rodolfo, de Vera, Maria Cristina, Albertini, Silvio, Ruepp, Stefan
Formato:	Texto
Lenguaje:	English
Publicado:	National Institute of Environmental Health Sciences 2004
Materias:	Toxicogenomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1277117/ https://www.ncbi.nlm.nih.gov/pubmed/15345370 http://dx.doi.org/10.1289/txg.7036

Ejemplares similares

Prediction of Toxicant-Specific Gene Expression Signatures after Chemotherapeutic Treatment of Breast Cell Lines
por: Troester, Melissa A., et al.
Publicado: (2004)

DTNI: a novel toxicogenomics data analysis tool for identifying the molecular mechanisms underlying the adverse effects of toxic compounds
por: Hendrickx, Diana M., et al.
Publicado: (2016)

Biokinetics and Subchronic Toxic Effects of Oral Arsenite, Arsenate, Monomethylarsonic Acid, and Dimethylarsinic Acid in v-Ha-ras Transgenic (Tg.AC) Mice
por: Xie, Yaxiong, et al.
Publicado: (2004)

Global Gene Expression Profiling in Whole-Blood Samples from Individuals Exposed to Metal Fumes
por: Wang, Zhaoxi, et al.
Publicado: (2005)

Gene expression profiling in the lung tissue of cynomolgus monkeys in response to repeated exposure to welding fumes
por: Heo, Jeong-Doo, et al.
Publicado: (2009)

Gene Interaction Network Suggests Dioxin Induces a Significant Linkage between Aryl Hydrocarbon Receptor and Retinoic Acid Receptor Beta
por: Toyoshiba, Hiroyoshi, et al.
Publicado: (2004)

Valproic Acid Teratogenicity: A Toxicogenomics Approach
por: Kultima, Kim, et al.
Publicado: (2004)

Assessment of Prediction Confidence and Domain Extrapolation of Two Structure–Activity Relationship Models for Predicting Estrogen Receptor Binding Activity
por: Tong, Weida, et al.
Publicado: (2004)

Phenotypic Anchoring of Gene Expression Changes during Estrogen-Induced Uterine Growth
por: Moggs, Jonathan G., et al.
Publicado: (2004)

The TAO-Gen Algorithm for Identifying Gene Interaction Networks with Application to SOS Repair in E. coli
por: Yamanaka, Takeharu, et al.
Publicado: (2004)

Using Decision Forest to Classify Prostate Cancer Samples on the Basis of SELDI-TOF MS Data: Assessing Chance Correlation and Prediction Confidence
por: Tong, Weida, et al.
Publicado: (2004)

Renal Toxicogenomic Response to Chronic Uranyl Nitrate Insult in Mice
por: Taulan, Magali, et al.
Publicado: (2004)

Subchronic Exposure to TCDD, PeCDF, PCB126, and PCB153: Effect on Hepatic Gene Expression
por: Vezina, Chad M., et al.
Publicado: (2004)

Time Course of Gene Expression of Inflammatory Mediators in Rat Lung after Diesel Exhaust Particle Exposure
por: Rao, K. Murali Krishna, et al.
Publicado: (2005)

Discovery of Novel Biomarkers by Microarray Analysis of Peripheral Blood Mononuclear Cell Gene Expression in Benzene-Exposed Workers
por: Forrest, Matthew S., et al.
Publicado: (2005)

Comparative evaluation of the effects of short-term inhalation exposure to diesel engine exhaust on rat lung and brain
por: van Berlo, Damien, et al.
Publicado: (2010)

Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach
por: Krug, Anne K., et al.
Publicado: (2012)

Identification of sample annotation errors in gene expression datasets
por: Lohr, Miriam, et al.
Publicado: (2015)

Interindividual variation in gene expression responses and metabolite formation in acetaminophen-exposed primary human hepatocytes
por: Jetten, Marlon J. A., et al.
Publicado: (2015)

Toxicogenomic assessment of liver responses following subchronic exposure to furan in Fischer F344 rats
por: Dong, Hongyan, et al.
Publicado: (2015)

Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq
por: Limonciel, Alice, et al.
Publicado: (2018)

Association between polymorphism of GSTP1, GSTT1, GSTM1 and CYP2E1 genes and susceptibility to benzene-induced hematotoxicity
por: Nourozi, Mohamad Amin, et al.
Publicado: (2017)

Genome-wide mapping and analysis of aryl hydrocarbon receptor (AHR)- and aryl hydrocarbon receptor repressor (AHRR)-binding sites in human breast cancer cells
por: Yang, Sunny Y., et al.
Publicado: (2017)

A novel regulatory network among LncRpa, CircRar1, MiR-671 and apoptotic genes promotes lead-induced neuronal cell apoptosis
por: Nan, Aruo, et al.
Publicado: (2016)

Metabolomic analysis to discriminate drug-induced liver injury (DILI) phenotypes
por: Quintás, Guillermo, et al.
Publicado: (2021)

Toxicokinetics and toxicodynamics of the fentanyl homologs cyclopropanoyl-1-benzyl-4´-fluoro-4-anilinopiperidine and furanoyl-1-benzyl-4-anilinopiperidine
por: Gampfer, Tanja M., et al.
Publicado: (2020)

Pharmacokinetics and toxicity evaluation following oral exposure to bisphenol F
por: Lee, Somin, et al.
Publicado: (2022)

Transcriptional profiling of the response to the trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine revealed activation of the eIF2α/ATF4 integrated stress response in two in vitro placental models
por: Elkin, Elana R., et al.
Publicado: (2021)

New insights into the mechanisms underlying 5-fluorouracil-induced intestinal toxicity based on transcriptomic and metabolomic responses in human intestinal organoids
por: Rodrigues, Daniela, et al.
Publicado: (2021)

Proteomic profiling of murine biliary-derived hepatic organoids and their capacity for drug disposition, bioactivation and detoxification
por: Howell, Lawrence, et al.
Publicado: (2021)

Metabolic profiling as a powerful tool for the analysis of cellular alterations caused by 20 mycotoxins in HepG2 cells
por: Gerdemann, Andrea, et al.
Publicado: (2022)

Application of high throughput in vitro metabolomics for hepatotoxicity mode of action characterization and mechanistic-anchored point of departure derivation: a case study with nitrofurantoin
por: Ramirez-Hincapie, Sabina, et al.
Publicado: (2023)

Toxicometabolomics of the new psychoactive substances α-PBP and α-PEP studied in HepaRG cell incubates by means of untargeted metabolomics revealed unexpected amino acid adducts
por: Manier, Sascha K., et al.
Publicado: (2020)

Assessment of the impact of mitochondrial genotype upon drug-induced mitochondrial dysfunction in platelets derived from healthy volunteers
por: Ball, Amy L., et al.
Publicado: (2021)

A TMT-based shotgun proteomics uncovers overexpression of thrombospondin 1 as a contributor in pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome
por: Wang, Weiqian, et al.
Publicado: (2022)

Going deeper into the toxicokinetics of synthetic cannabinoids: in vitro contribution of human carboxylesterases
por: Wagmann, Lea, et al.
Publicado: (2022)

Proteomic analysis of hepatic effects of phenobarbital in mice with humanized liver
por: Sprenger, Heike, et al.
Publicado: (2022)

Gene Expression Analysis of the Hepatotoxicant Methapyrilene in Primary Rat Hepatocytes: An Interlaboratory Study
por: Beekman, Johanna M., et al.
Publicado: (2006)

Discrimination of Carcinogens by Hepatic Transcript Profiling in Rats Following 28-day Administration
por: Matsumoto, Hiroshi, et al.
Publicado: (2009)

Rheumatoid arthritis – class prediction by autoreactivity profiles
por: Bergholz, R, et al.
Publicado: (2003)

Cannot write session to /tmp/vufind_sessions/sess_rv5bmlh29lo298hnq9rr2nmtno