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Combustion-derived nanoparticles: A review of their toxicology following inhalation exposure

This review considers the molecular toxicology of combustion-derived nanoparticles (CDNP) following inhalation exposure. CDNP originate from a number of sources and in this review we consider diesel soot, welding fume, carbon black and coal fly ash. A substantial literature demonstrates that these p...

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Autores principales: Donaldson, Ken, Tran, Lang, Jimenez, Luis Albert, Duffin, Rodger, Newby, David E, Mills, Nicholas, MacNee, William, Stone, Vicki
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1280930/
https://www.ncbi.nlm.nih.gov/pubmed/16242040
http://dx.doi.org/10.1186/1743-8977-2-10
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author Donaldson, Ken
Tran, Lang
Jimenez, Luis Albert
Duffin, Rodger
Newby, David E
Mills, Nicholas
MacNee, William
Stone, Vicki
author_facet Donaldson, Ken
Tran, Lang
Jimenez, Luis Albert
Duffin, Rodger
Newby, David E
Mills, Nicholas
MacNee, William
Stone, Vicki
author_sort Donaldson, Ken
collection PubMed
description This review considers the molecular toxicology of combustion-derived nanoparticles (CDNP) following inhalation exposure. CDNP originate from a number of sources and in this review we consider diesel soot, welding fume, carbon black and coal fly ash. A substantial literature demonstrates that these pose a hazard to the lungs through their potential to cause oxidative stress, inflammation and cancer; they also have the potential to redistribute to other organs following pulmonary deposition. These different CDNP show considerable heterogeneity in composition and solubility, meaning that oxidative stress may originate from different components depending on the particle under consideration. Key CDNP-associated properties of large surface area and the presence of metals and organics all have the potential to produce oxidative stress. CDNP may also exert genotoxic effects, depending on their composition. CDNP and their components also have the potential to translocate to the brain and also the blood, and thereby reach other targets such as the cardiovascular system, spleen and liver. CDNP therefore can be seen as a group of particulate toxins unified by a common mechanism of injury and properties of translocation which have the potential to mediate a range of adverse effects in the lungs and other organs and warrant further research.
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spelling pubmed-12809302005-11-10 Combustion-derived nanoparticles: A review of their toxicology following inhalation exposure Donaldson, Ken Tran, Lang Jimenez, Luis Albert Duffin, Rodger Newby, David E Mills, Nicholas MacNee, William Stone, Vicki Part Fibre Toxicol Review This review considers the molecular toxicology of combustion-derived nanoparticles (CDNP) following inhalation exposure. CDNP originate from a number of sources and in this review we consider diesel soot, welding fume, carbon black and coal fly ash. A substantial literature demonstrates that these pose a hazard to the lungs through their potential to cause oxidative stress, inflammation and cancer; they also have the potential to redistribute to other organs following pulmonary deposition. These different CDNP show considerable heterogeneity in composition and solubility, meaning that oxidative stress may originate from different components depending on the particle under consideration. Key CDNP-associated properties of large surface area and the presence of metals and organics all have the potential to produce oxidative stress. CDNP may also exert genotoxic effects, depending on their composition. CDNP and their components also have the potential to translocate to the brain and also the blood, and thereby reach other targets such as the cardiovascular system, spleen and liver. CDNP therefore can be seen as a group of particulate toxins unified by a common mechanism of injury and properties of translocation which have the potential to mediate a range of adverse effects in the lungs and other organs and warrant further research. BioMed Central 2005-10-21 /pmc/articles/PMC1280930/ /pubmed/16242040 http://dx.doi.org/10.1186/1743-8977-2-10 Text en Copyright © 2005 Donaldson et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Donaldson, Ken
Tran, Lang
Jimenez, Luis Albert
Duffin, Rodger
Newby, David E
Mills, Nicholas
MacNee, William
Stone, Vicki
Combustion-derived nanoparticles: A review of their toxicology following inhalation exposure
title Combustion-derived nanoparticles: A review of their toxicology following inhalation exposure
title_full Combustion-derived nanoparticles: A review of their toxicology following inhalation exposure
title_fullStr Combustion-derived nanoparticles: A review of their toxicology following inhalation exposure
title_full_unstemmed Combustion-derived nanoparticles: A review of their toxicology following inhalation exposure
title_short Combustion-derived nanoparticles: A review of their toxicology following inhalation exposure
title_sort combustion-derived nanoparticles: a review of their toxicology following inhalation exposure
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1280930/
https://www.ncbi.nlm.nih.gov/pubmed/16242040
http://dx.doi.org/10.1186/1743-8977-2-10
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