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Small bowel Gastrointestinal Stromal Tumors can physiologically alter gut motility before causing mechanical obstruction

BACKGROUND: Gastro Intestinal Stromal Tumors (GISTs) are rare stromal neoplasms that represent the most common mesenchymal tumor of the G.I. tract, accounting for 5% of all sarcomas [1,2]. Originating from interstitial cells of Cajal, which are regulators of gut peristalsis, they are preferentially...

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Autores principales: Kothari, Manish S, Kosmoliaptsis, Vasilis, Meyrick-Thomas, John
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1282588/
https://www.ncbi.nlm.nih.gov/pubmed/16250914
http://dx.doi.org/10.1186/1477-7800-2-24
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author Kothari, Manish S
Kosmoliaptsis, Vasilis
Meyrick-Thomas, John
author_facet Kothari, Manish S
Kosmoliaptsis, Vasilis
Meyrick-Thomas, John
author_sort Kothari, Manish S
collection PubMed
description BACKGROUND: Gastro Intestinal Stromal Tumors (GISTs) are rare stromal neoplasms that represent the most common mesenchymal tumor of the G.I. tract, accounting for 5% of all sarcomas [1,2]. Originating from interstitial cells of Cajal, which are regulators of gut peristalsis, they are preferentially located in the stomach and the small intestine [3] and clinical presentation is variable, ranging from vague complaints to major G.I. bleeding. Surgical resection is the mainstay of treatment for patients with resectable GIST and 5-year survival ranges from 21% to 88% in different series depending on risk grading and completeness of surgical resection [4,5]. Imatinib mesylate, a tyrosine kinase inhibitor, provides an encouraging option for treating high risk GISTs. CASE PRESENTATION: We report the case of a 62-year-old lady who had been diagnosed and being treated unsuccessfully for Irritable bowel syndrome for 11 years and eventually found to have an obstructing small bowel GIST. CONCLUSION: The symptoms from GIST may mimic those of irritable bowel syndrome. A physiological alteration in gut peristalsis resulting from neoplastic transformation of the interstitial cells of Cajal, is a hypothesis that could explain this presentation. An alternative diagnosis should be considered when treating patients with irritable bowel syndrome who fail to respond for a prolonged period.
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spelling pubmed-12825882005-11-13 Small bowel Gastrointestinal Stromal Tumors can physiologically alter gut motility before causing mechanical obstruction Kothari, Manish S Kosmoliaptsis, Vasilis Meyrick-Thomas, John Int Semin Surg Oncol Case Report BACKGROUND: Gastro Intestinal Stromal Tumors (GISTs) are rare stromal neoplasms that represent the most common mesenchymal tumor of the G.I. tract, accounting for 5% of all sarcomas [1,2]. Originating from interstitial cells of Cajal, which are regulators of gut peristalsis, they are preferentially located in the stomach and the small intestine [3] and clinical presentation is variable, ranging from vague complaints to major G.I. bleeding. Surgical resection is the mainstay of treatment for patients with resectable GIST and 5-year survival ranges from 21% to 88% in different series depending on risk grading and completeness of surgical resection [4,5]. Imatinib mesylate, a tyrosine kinase inhibitor, provides an encouraging option for treating high risk GISTs. CASE PRESENTATION: We report the case of a 62-year-old lady who had been diagnosed and being treated unsuccessfully for Irritable bowel syndrome for 11 years and eventually found to have an obstructing small bowel GIST. CONCLUSION: The symptoms from GIST may mimic those of irritable bowel syndrome. A physiological alteration in gut peristalsis resulting from neoplastic transformation of the interstitial cells of Cajal, is a hypothesis that could explain this presentation. An alternative diagnosis should be considered when treating patients with irritable bowel syndrome who fail to respond for a prolonged period. BioMed Central 2005-10-26 /pmc/articles/PMC1282588/ /pubmed/16250914 http://dx.doi.org/10.1186/1477-7800-2-24 Text en Copyright © 2005 Kothari et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kothari, Manish S
Kosmoliaptsis, Vasilis
Meyrick-Thomas, John
Small bowel Gastrointestinal Stromal Tumors can physiologically alter gut motility before causing mechanical obstruction
title Small bowel Gastrointestinal Stromal Tumors can physiologically alter gut motility before causing mechanical obstruction
title_full Small bowel Gastrointestinal Stromal Tumors can physiologically alter gut motility before causing mechanical obstruction
title_fullStr Small bowel Gastrointestinal Stromal Tumors can physiologically alter gut motility before causing mechanical obstruction
title_full_unstemmed Small bowel Gastrointestinal Stromal Tumors can physiologically alter gut motility before causing mechanical obstruction
title_short Small bowel Gastrointestinal Stromal Tumors can physiologically alter gut motility before causing mechanical obstruction
title_sort small bowel gastrointestinal stromal tumors can physiologically alter gut motility before causing mechanical obstruction
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1282588/
https://www.ncbi.nlm.nih.gov/pubmed/16250914
http://dx.doi.org/10.1186/1477-7800-2-24
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