Cargando…
The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumonia
We have shown previously that surfactant protein D (SP-D) binds and agglutinates Streptococcus pneumoniae in vitro. In this study, the role of SP-D in innate immunity against S. pneumoniae was investigated in vivo, by comparing the outcome of intranasal infection in surfactant protein D deficient (S...
Autores principales: | , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2005
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1282592/ https://www.ncbi.nlm.nih.gov/pubmed/16255775 http://dx.doi.org/10.1186/1465-9921-6-126 |
_version_ | 1782126140996976640 |
---|---|
author | Jounblat, R Clark, H Eggleton, P Hawgood, S Andrew, PW Kadioglu, A |
author_facet | Jounblat, R Clark, H Eggleton, P Hawgood, S Andrew, PW Kadioglu, A |
author_sort | Jounblat, R |
collection | PubMed |
description | We have shown previously that surfactant protein D (SP-D) binds and agglutinates Streptococcus pneumoniae in vitro. In this study, the role of SP-D in innate immunity against S. pneumoniae was investigated in vivo, by comparing the outcome of intranasal infection in surfactant protein D deficient (SP-D-/-) to wildtype mice (SP-D+/+). Deficiency of SP-D was associated with enhanced colonisation and infection of the upper and lower respiratory tract and earlier onset and longer persistence of bacteraemia. Recruitment of neutrophils to inflammatory sites in the lung was similar in both strains mice in the first 24 hrs post-infection, but different by 48 hrs. T cell influx was greatly enhanced in SP-D-/- mice as compared to SP-D+/+ mice. Our data provides evidence that SP-D has a significant role to play in the clearance of pneumococci during the early stages of infection in both pulmonary sites and blood. |
format | Text |
id | pubmed-1282592 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-12825922005-11-13 The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumonia Jounblat, R Clark, H Eggleton, P Hawgood, S Andrew, PW Kadioglu, A Respir Res Research We have shown previously that surfactant protein D (SP-D) binds and agglutinates Streptococcus pneumoniae in vitro. In this study, the role of SP-D in innate immunity against S. pneumoniae was investigated in vivo, by comparing the outcome of intranasal infection in surfactant protein D deficient (SP-D-/-) to wildtype mice (SP-D+/+). Deficiency of SP-D was associated with enhanced colonisation and infection of the upper and lower respiratory tract and earlier onset and longer persistence of bacteraemia. Recruitment of neutrophils to inflammatory sites in the lung was similar in both strains mice in the first 24 hrs post-infection, but different by 48 hrs. T cell influx was greatly enhanced in SP-D-/- mice as compared to SP-D+/+ mice. Our data provides evidence that SP-D has a significant role to play in the clearance of pneumococci during the early stages of infection in both pulmonary sites and blood. BioMed Central 2005 2005-10-28 /pmc/articles/PMC1282592/ /pubmed/16255775 http://dx.doi.org/10.1186/1465-9921-6-126 Text en Copyright © 2005 Jounblat et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Jounblat, R Clark, H Eggleton, P Hawgood, S Andrew, PW Kadioglu, A The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumonia |
title | The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumonia |
title_full | The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumonia |
title_fullStr | The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumonia |
title_full_unstemmed | The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumonia |
title_short | The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumonia |
title_sort | role of surfactant protein d in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumonia |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1282592/ https://www.ncbi.nlm.nih.gov/pubmed/16255775 http://dx.doi.org/10.1186/1465-9921-6-126 |
work_keys_str_mv | AT jounblatr theroleofsurfactantproteindinthecolonisationoftherespiratorytractandonsetofbacteraemiaduringpneumococcalpneumonia AT clarkh theroleofsurfactantproteindinthecolonisationoftherespiratorytractandonsetofbacteraemiaduringpneumococcalpneumonia AT eggletonp theroleofsurfactantproteindinthecolonisationoftherespiratorytractandonsetofbacteraemiaduringpneumococcalpneumonia AT hawgoods theroleofsurfactantproteindinthecolonisationoftherespiratorytractandonsetofbacteraemiaduringpneumococcalpneumonia AT andrewpw theroleofsurfactantproteindinthecolonisationoftherespiratorytractandonsetofbacteraemiaduringpneumococcalpneumonia AT kadioglua theroleofsurfactantproteindinthecolonisationoftherespiratorytractandonsetofbacteraemiaduringpneumococcalpneumonia AT jounblatr roleofsurfactantproteindinthecolonisationoftherespiratorytractandonsetofbacteraemiaduringpneumococcalpneumonia AT clarkh roleofsurfactantproteindinthecolonisationoftherespiratorytractandonsetofbacteraemiaduringpneumococcalpneumonia AT eggletonp roleofsurfactantproteindinthecolonisationoftherespiratorytractandonsetofbacteraemiaduringpneumococcalpneumonia AT hawgoods roleofsurfactantproteindinthecolonisationoftherespiratorytractandonsetofbacteraemiaduringpneumococcalpneumonia AT andrewpw roleofsurfactantproteindinthecolonisationoftherespiratorytractandonsetofbacteraemiaduringpneumococcalpneumonia AT kadioglua roleofsurfactantproteindinthecolonisationoftherespiratorytractandonsetofbacteraemiaduringpneumococcalpneumonia |