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Regulation of epidermal differentiation by a Distal-less homeodomain gene
The Distal-less-related homeodomain gene Dlx3 is expressed in terminally differentiated murine epidermal cells. Ectopic expression of this gene in the basal cell layer of transgenic skin results in a severely abnormal epidermal phenotype and leads to perinatal lethality. The basal cells of affected...
Formato: | Texto |
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Lenguaje: | English |
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The Rockefeller University Press
1996
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1283140/ https://www.ncbi.nlm.nih.gov/pubmed/8991098 |
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collection | PubMed |
description | The Distal-less-related homeodomain gene Dlx3 is expressed in terminally differentiated murine epidermal cells. Ectopic expression of this gene in the basal cell layer of transgenic skin results in a severely abnormal epidermal phenotype and leads to perinatal lethality. The basal cells of affected mice ceased to proliferate, and expressed the profilaggrin and loricrin genes which are normally transcribed only in the latest stages of epidermal differentiation. All suprabasal cell types were diminished and the stratum corneum was reduced to a single layer. These data indicate that Dlx3 misexpression results in transformation of basal cells into more differentiated keratinocytes, suggesting that this homeoprotein is an important regulator of epidermal differentiation. |
format | Text |
id | pubmed-1283140 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1996 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-12831402008-05-01 Regulation of epidermal differentiation by a Distal-less homeodomain gene J Cell Biol Articles The Distal-less-related homeodomain gene Dlx3 is expressed in terminally differentiated murine epidermal cells. Ectopic expression of this gene in the basal cell layer of transgenic skin results in a severely abnormal epidermal phenotype and leads to perinatal lethality. The basal cells of affected mice ceased to proliferate, and expressed the profilaggrin and loricrin genes which are normally transcribed only in the latest stages of epidermal differentiation. All suprabasal cell types were diminished and the stratum corneum was reduced to a single layer. These data indicate that Dlx3 misexpression results in transformation of basal cells into more differentiated keratinocytes, suggesting that this homeoprotein is an important regulator of epidermal differentiation. The Rockefeller University Press 1996-12-02 /pmc/articles/PMC1283140/ /pubmed/8991098 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Articles Regulation of epidermal differentiation by a Distal-less homeodomain gene |
title | Regulation of epidermal differentiation by a Distal-less homeodomain gene |
title_full | Regulation of epidermal differentiation by a Distal-less homeodomain gene |
title_fullStr | Regulation of epidermal differentiation by a Distal-less homeodomain gene |
title_full_unstemmed | Regulation of epidermal differentiation by a Distal-less homeodomain gene |
title_short | Regulation of epidermal differentiation by a Distal-less homeodomain gene |
title_sort | regulation of epidermal differentiation by a distal-less homeodomain gene |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1283140/ https://www.ncbi.nlm.nih.gov/pubmed/8991098 |