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Theta Rhythms Coordinate Hippocampal–Prefrontal Interactions in a Spatial Memory Task
Decision-making requires the coordinated activity of diverse brain structures. For example, in maze-based tasks, the prefrontal cortex must integrate spatial information encoded in the hippocampus with mnemonic information concerning route and task rules in order to direct behavior appropriately. Us...
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Formato: | Texto |
Lenguaje: | English |
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Public Library of Science
2005
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1283536/ https://www.ncbi.nlm.nih.gov/pubmed/16279838 http://dx.doi.org/10.1371/journal.pbio.0030402 |
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author | Jones, Matthew W Wilson, Matthew A |
author_facet | Jones, Matthew W Wilson, Matthew A |
author_sort | Jones, Matthew W |
collection | PubMed |
description | Decision-making requires the coordinated activity of diverse brain structures. For example, in maze-based tasks, the prefrontal cortex must integrate spatial information encoded in the hippocampus with mnemonic information concerning route and task rules in order to direct behavior appropriately. Using simultaneous tetrode recordings from CA1 of the rat hippocampus and medial prefrontal cortex, we show that correlated firing in the two structures is selectively enhanced during behavior that recruits spatial working memory, allowing the integration of hippocampal spatial information into a broader, decision-making network. The increased correlations are paralleled by enhanced coupling of the two structures in the 4- to 12-Hz theta-frequency range. Thus the coordination of theta rhythms may constitute a general mechanism through which the relative timing of disparate neural activities can be controlled, allowing specialized brain structures to both encode information independently and to interact selectively according to current behavioral demands. |
format | Text |
id | pubmed-1283536 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-12835362005-11-15 Theta Rhythms Coordinate Hippocampal–Prefrontal Interactions in a Spatial Memory Task Jones, Matthew W Wilson, Matthew A PLoS Biol Research Article Decision-making requires the coordinated activity of diverse brain structures. For example, in maze-based tasks, the prefrontal cortex must integrate spatial information encoded in the hippocampus with mnemonic information concerning route and task rules in order to direct behavior appropriately. Using simultaneous tetrode recordings from CA1 of the rat hippocampus and medial prefrontal cortex, we show that correlated firing in the two structures is selectively enhanced during behavior that recruits spatial working memory, allowing the integration of hippocampal spatial information into a broader, decision-making network. The increased correlations are paralleled by enhanced coupling of the two structures in the 4- to 12-Hz theta-frequency range. Thus the coordination of theta rhythms may constitute a general mechanism through which the relative timing of disparate neural activities can be controlled, allowing specialized brain structures to both encode information independently and to interact selectively according to current behavioral demands. Public Library of Science 2005-12 2005-11-15 /pmc/articles/PMC1283536/ /pubmed/16279838 http://dx.doi.org/10.1371/journal.pbio.0030402 Text en Copyright: © 2005 Jones and Wilson. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Jones, Matthew W Wilson, Matthew A Theta Rhythms Coordinate Hippocampal–Prefrontal Interactions in a Spatial Memory Task |
title | Theta Rhythms Coordinate Hippocampal–Prefrontal Interactions in a Spatial Memory Task |
title_full | Theta Rhythms Coordinate Hippocampal–Prefrontal Interactions in a Spatial Memory Task |
title_fullStr | Theta Rhythms Coordinate Hippocampal–Prefrontal Interactions in a Spatial Memory Task |
title_full_unstemmed | Theta Rhythms Coordinate Hippocampal–Prefrontal Interactions in a Spatial Memory Task |
title_short | Theta Rhythms Coordinate Hippocampal–Prefrontal Interactions in a Spatial Memory Task |
title_sort | theta rhythms coordinate hippocampal–prefrontal interactions in a spatial memory task |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1283536/ https://www.ncbi.nlm.nih.gov/pubmed/16279838 http://dx.doi.org/10.1371/journal.pbio.0030402 |
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