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Bone loss: Factors that regulate osteoclast differentiation - an update

Osteoclast activation is a critical cellular process for pathological bone resorption, such as erosions in rheumatoid arthritis (RA) or generalized bone loss. Among many factors triggering excessive osteoclast activity, cytokines such as IL-1 or tumour necrosis factor (TNF)-α play a central role. Ne...

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Detalles Bibliográficos
Autores principales: Roux, Sophie, Orcel, Philippe
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2000
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC128874/
https://www.ncbi.nlm.nih.gov/pubmed/11094458
http://dx.doi.org/10.1186/ar127
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author Roux, Sophie
Orcel, Philippe
author_facet Roux, Sophie
Orcel, Philippe
author_sort Roux, Sophie
collection PubMed
description Osteoclast activation is a critical cellular process for pathological bone resorption, such as erosions in rheumatoid arthritis (RA) or generalized bone loss. Among many factors triggering excessive osteoclast activity, cytokines such as IL-1 or tumour necrosis factor (TNF)-α play a central role. New members of the TNF receptor ligand family (namely receptor activator of nuclear factor-κB [RANK] and RANK ligand [RANKL]) have been discovered whose cross-interaction is mandatory for the differentiation of osteoclasts from hemopoietic precursors, in both physiological and pathological situations. Osteoprotegerin, a decoy receptor which blocks this interaction, decreases osteoclast activity and could have a fascinating therapeutic potential in conditions associated with upregulated bone resorption.
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spelling pubmed-1288742002-10-28 Bone loss: Factors that regulate osteoclast differentiation - an update Roux, Sophie Orcel, Philippe Arthritis Res Review Osteoclast activation is a critical cellular process for pathological bone resorption, such as erosions in rheumatoid arthritis (RA) or generalized bone loss. Among many factors triggering excessive osteoclast activity, cytokines such as IL-1 or tumour necrosis factor (TNF)-α play a central role. New members of the TNF receptor ligand family (namely receptor activator of nuclear factor-κB [RANK] and RANK ligand [RANKL]) have been discovered whose cross-interaction is mandatory for the differentiation of osteoclasts from hemopoietic precursors, in both physiological and pathological situations. Osteoprotegerin, a decoy receptor which blocks this interaction, decreases osteoclast activity and could have a fascinating therapeutic potential in conditions associated with upregulated bone resorption. BioMed Central 2000 2000-09-06 /pmc/articles/PMC128874/ /pubmed/11094458 http://dx.doi.org/10.1186/ar127 Text en Copyright © 2000 Current Science Ltd
spellingShingle Review
Roux, Sophie
Orcel, Philippe
Bone loss: Factors that regulate osteoclast differentiation - an update
title Bone loss: Factors that regulate osteoclast differentiation - an update
title_full Bone loss: Factors that regulate osteoclast differentiation - an update
title_fullStr Bone loss: Factors that regulate osteoclast differentiation - an update
title_full_unstemmed Bone loss: Factors that regulate osteoclast differentiation - an update
title_short Bone loss: Factors that regulate osteoclast differentiation - an update
title_sort bone loss: factors that regulate osteoclast differentiation - an update
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC128874/
https://www.ncbi.nlm.nih.gov/pubmed/11094458
http://dx.doi.org/10.1186/ar127
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