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Bone loss: Factors that regulate osteoclast differentiation - an update
Osteoclast activation is a critical cellular process for pathological bone resorption, such as erosions in rheumatoid arthritis (RA) or generalized bone loss. Among many factors triggering excessive osteoclast activity, cytokines such as IL-1 or tumour necrosis factor (TNF)-α play a central role. Ne...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2000
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC128874/ https://www.ncbi.nlm.nih.gov/pubmed/11094458 http://dx.doi.org/10.1186/ar127 |
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author | Roux, Sophie Orcel, Philippe |
author_facet | Roux, Sophie Orcel, Philippe |
author_sort | Roux, Sophie |
collection | PubMed |
description | Osteoclast activation is a critical cellular process for pathological bone resorption, such as erosions in rheumatoid arthritis (RA) or generalized bone loss. Among many factors triggering excessive osteoclast activity, cytokines such as IL-1 or tumour necrosis factor (TNF)-α play a central role. New members of the TNF receptor ligand family (namely receptor activator of nuclear factor-κB [RANK] and RANK ligand [RANKL]) have been discovered whose cross-interaction is mandatory for the differentiation of osteoclasts from hemopoietic precursors, in both physiological and pathological situations. Osteoprotegerin, a decoy receptor which blocks this interaction, decreases osteoclast activity and could have a fascinating therapeutic potential in conditions associated with upregulated bone resorption. |
format | Text |
id | pubmed-128874 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2000 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-1288742002-10-28 Bone loss: Factors that regulate osteoclast differentiation - an update Roux, Sophie Orcel, Philippe Arthritis Res Review Osteoclast activation is a critical cellular process for pathological bone resorption, such as erosions in rheumatoid arthritis (RA) or generalized bone loss. Among many factors triggering excessive osteoclast activity, cytokines such as IL-1 or tumour necrosis factor (TNF)-α play a central role. New members of the TNF receptor ligand family (namely receptor activator of nuclear factor-κB [RANK] and RANK ligand [RANKL]) have been discovered whose cross-interaction is mandatory for the differentiation of osteoclasts from hemopoietic precursors, in both physiological and pathological situations. Osteoprotegerin, a decoy receptor which blocks this interaction, decreases osteoclast activity and could have a fascinating therapeutic potential in conditions associated with upregulated bone resorption. BioMed Central 2000 2000-09-06 /pmc/articles/PMC128874/ /pubmed/11094458 http://dx.doi.org/10.1186/ar127 Text en Copyright © 2000 Current Science Ltd |
spellingShingle | Review Roux, Sophie Orcel, Philippe Bone loss: Factors that regulate osteoclast differentiation - an update |
title | Bone loss: Factors that regulate osteoclast differentiation - an update |
title_full | Bone loss: Factors that regulate osteoclast differentiation - an update |
title_fullStr | Bone loss: Factors that regulate osteoclast differentiation - an update |
title_full_unstemmed | Bone loss: Factors that regulate osteoclast differentiation - an update |
title_short | Bone loss: Factors that regulate osteoclast differentiation - an update |
title_sort | bone loss: factors that regulate osteoclast differentiation - an update |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC128874/ https://www.ncbi.nlm.nih.gov/pubmed/11094458 http://dx.doi.org/10.1186/ar127 |
work_keys_str_mv | AT rouxsophie bonelossfactorsthatregulateosteoclastdifferentiationanupdate AT orcelphilippe bonelossfactorsthatregulateosteoclastdifferentiationanupdate |