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Cell-cell interactions in synovitis: Antigen presenting cells and T cell interaction in rheumatoid arthritis

The synovial tissue in rheumatoid arthritis (RA) patients is enriched with mature antigen presenting cells (APCs) and many T lymphocytes. Interactions between APCs and T cells are essential for the initiation and amplification of T-cell-dependent immune responses, and may therefore play an important...

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Detalles Bibliográficos
Autores principales: Aarvak, Tanja, Natvig, Jacob B
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2001
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC128879/
https://www.ncbi.nlm.nih.gov/pubmed/11178123
http://dx.doi.org/10.1186/ar135
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author Aarvak, Tanja
Natvig, Jacob B
author_facet Aarvak, Tanja
Natvig, Jacob B
author_sort Aarvak, Tanja
collection PubMed
description The synovial tissue in rheumatoid arthritis (RA) patients is enriched with mature antigen presenting cells (APCs) and many T lymphocytes. Interactions between APCs and T cells are essential for the initiation and amplification of T-cell-dependent immune responses, and may therefore play an important role in the chronic inflammatory processes in the synovium. The nature of the antigen(s) involved in RA still remains elusive. However, interactions and signaling through the costimulatory molecules CD28-CD80/86 and CD40-CD40L are critical during APC–T cell interaction for optimal cell activation. This review discusses how such costimulatory signals can be involved in the initiation and amplification of the inflammatory reactions in the synovium. Blocking of the signaling pathways involved in APC–T cell interactions might provide a specific immuno-therapeutic approach for the treatment of RA.
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spelling pubmed-1288792002-10-28 Cell-cell interactions in synovitis: Antigen presenting cells and T cell interaction in rheumatoid arthritis Aarvak, Tanja Natvig, Jacob B Arthritis Res Review The synovial tissue in rheumatoid arthritis (RA) patients is enriched with mature antigen presenting cells (APCs) and many T lymphocytes. Interactions between APCs and T cells are essential for the initiation and amplification of T-cell-dependent immune responses, and may therefore play an important role in the chronic inflammatory processes in the synovium. The nature of the antigen(s) involved in RA still remains elusive. However, interactions and signaling through the costimulatory molecules CD28-CD80/86 and CD40-CD40L are critical during APC–T cell interaction for optimal cell activation. This review discusses how such costimulatory signals can be involved in the initiation and amplification of the inflammatory reactions in the synovium. Blocking of the signaling pathways involved in APC–T cell interactions might provide a specific immuno-therapeutic approach for the treatment of RA. BioMed Central 2001 2000-10-27 /pmc/articles/PMC128879/ /pubmed/11178123 http://dx.doi.org/10.1186/ar135 Text en Copyright © 2000 BioMed Central Ltd on behalf of the copyright holders
spellingShingle Review
Aarvak, Tanja
Natvig, Jacob B
Cell-cell interactions in synovitis: Antigen presenting cells and T cell interaction in rheumatoid arthritis
title Cell-cell interactions in synovitis: Antigen presenting cells and T cell interaction in rheumatoid arthritis
title_full Cell-cell interactions in synovitis: Antigen presenting cells and T cell interaction in rheumatoid arthritis
title_fullStr Cell-cell interactions in synovitis: Antigen presenting cells and T cell interaction in rheumatoid arthritis
title_full_unstemmed Cell-cell interactions in synovitis: Antigen presenting cells and T cell interaction in rheumatoid arthritis
title_short Cell-cell interactions in synovitis: Antigen presenting cells and T cell interaction in rheumatoid arthritis
title_sort cell-cell interactions in synovitis: antigen presenting cells and t cell interaction in rheumatoid arthritis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC128879/
https://www.ncbi.nlm.nih.gov/pubmed/11178123
http://dx.doi.org/10.1186/ar135
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