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T-cell-mediated control of autoimmunity

Inflammatory responses provoked by pathogens are antigen-specific in their induction but are nonspecific in their effects. Consequently, they are potentially damaging to the host that produces them. In addition, the immune system can respond specifically to self antigens, thereby giving rise to auto...

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Detalles Bibliográficos
Autor principal: Mason, Don
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2001
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC128888/
https://www.ncbi.nlm.nih.gov/pubmed/11299052
http://dx.doi.org/10.1186/ar289
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author Mason, Don
author_facet Mason, Don
author_sort Mason, Don
collection PubMed
description Inflammatory responses provoked by pathogens are antigen-specific in their induction but are nonspecific in their effects. Consequently, they are potentially damaging to the host that produces them. In addition, the immune system can respond specifically to self antigens, thereby giving rise to autoimmune diseases. A number of regulatory mechanisms have evolved to prevent such adverse effects. One of these has been shown to depend on a particular subset of CD4(+) T cells that appears to have evolved specifically for this protective role. These cells are termed regulatory T cells. This review summarises what is known about them.
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spelling pubmed-1288882002-10-28 T-cell-mediated control of autoimmunity Mason, Don Arthritis Res Commentary Inflammatory responses provoked by pathogens are antigen-specific in their induction but are nonspecific in their effects. Consequently, they are potentially damaging to the host that produces them. In addition, the immune system can respond specifically to self antigens, thereby giving rise to autoimmune diseases. A number of regulatory mechanisms have evolved to prevent such adverse effects. One of these has been shown to depend on a particular subset of CD4(+) T cells that appears to have evolved specifically for this protective role. These cells are termed regulatory T cells. This review summarises what is known about them. BioMed Central 2001 2001-02-01 /pmc/articles/PMC128888/ /pubmed/11299052 http://dx.doi.org/10.1186/ar289 Text en Copyright © 2001 BioMed Central Ltd
spellingShingle Commentary
Mason, Don
T-cell-mediated control of autoimmunity
title T-cell-mediated control of autoimmunity
title_full T-cell-mediated control of autoimmunity
title_fullStr T-cell-mediated control of autoimmunity
title_full_unstemmed T-cell-mediated control of autoimmunity
title_short T-cell-mediated control of autoimmunity
title_sort t-cell-mediated control of autoimmunity
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC128888/
https://www.ncbi.nlm.nih.gov/pubmed/11299052
http://dx.doi.org/10.1186/ar289
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