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Genetic markers of osteoarticular disorders: facts and hopes

Osteoarthritis and osteoporosis are the two most common age-related chronic disorders of articular joints and skeleton, representing a major public health problem in most developed countries. Apart from being influenced by environmental factors, both disorders have a strong genetic component, and th...

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Detalles Bibliográficos
Autores principales: Brandi, Maria Luisa, Gennari, Luigi, Cerinic, Marco Matucci, Becherini, Lucia, Falchetti, Alberto, Masi, Laura, Gennari, Carlo, Reginster, Jean-Yves
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2001
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC128904/
https://www.ncbi.nlm.nih.gov/pubmed/11549368
http://dx.doi.org/10.1186/ar316
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author Brandi, Maria Luisa
Gennari, Luigi
Cerinic, Marco Matucci
Becherini, Lucia
Falchetti, Alberto
Masi, Laura
Gennari, Carlo
Reginster, Jean-Yves
author_facet Brandi, Maria Luisa
Gennari, Luigi
Cerinic, Marco Matucci
Becherini, Lucia
Falchetti, Alberto
Masi, Laura
Gennari, Carlo
Reginster, Jean-Yves
author_sort Brandi, Maria Luisa
collection PubMed
description Osteoarthritis and osteoporosis are the two most common age-related chronic disorders of articular joints and skeleton, representing a major public health problem in most developed countries. Apart from being influenced by environmental factors, both disorders have a strong genetic component, and there is now considerable evidence from large population studies that these two disorders are inversely related. Thus, an accurate analysis of the genetic component of one of these two multifactorial diseases may provide data of interest for the other. However, the existence of confounding factors must always be borne in mind in interpreting the genetic analysis. In addition, each patient must be given an accurate clinical evaluation, including family history, history of drug treatments, lifestyle, and environment, in order to reduce the background bias. Here, we review the impact of recent work in molecular genetics suggesting that powerful molecular biology techniques will soon make possible both a rapid accumulation of data on the genetics of both disorders and the development of novel diagnostic, prognostic, and therapeutic approaches.
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spelling pubmed-1289042002-10-28 Genetic markers of osteoarticular disorders: facts and hopes Brandi, Maria Luisa Gennari, Luigi Cerinic, Marco Matucci Becherini, Lucia Falchetti, Alberto Masi, Laura Gennari, Carlo Reginster, Jean-Yves Arthritis Res Review Osteoarthritis and osteoporosis are the two most common age-related chronic disorders of articular joints and skeleton, representing a major public health problem in most developed countries. Apart from being influenced by environmental factors, both disorders have a strong genetic component, and there is now considerable evidence from large population studies that these two disorders are inversely related. Thus, an accurate analysis of the genetic component of one of these two multifactorial diseases may provide data of interest for the other. However, the existence of confounding factors must always be borne in mind in interpreting the genetic analysis. In addition, each patient must be given an accurate clinical evaluation, including family history, history of drug treatments, lifestyle, and environment, in order to reduce the background bias. Here, we review the impact of recent work in molecular genetics suggesting that powerful molecular biology techniques will soon make possible both a rapid accumulation of data on the genetics of both disorders and the development of novel diagnostic, prognostic, and therapeutic approaches. BioMed Central 2001 2001-07-04 /pmc/articles/PMC128904/ /pubmed/11549368 http://dx.doi.org/10.1186/ar316 Text en Copyright © 2001 BioMed Central Ltd
spellingShingle Review
Brandi, Maria Luisa
Gennari, Luigi
Cerinic, Marco Matucci
Becherini, Lucia
Falchetti, Alberto
Masi, Laura
Gennari, Carlo
Reginster, Jean-Yves
Genetic markers of osteoarticular disorders: facts and hopes
title Genetic markers of osteoarticular disorders: facts and hopes
title_full Genetic markers of osteoarticular disorders: facts and hopes
title_fullStr Genetic markers of osteoarticular disorders: facts and hopes
title_full_unstemmed Genetic markers of osteoarticular disorders: facts and hopes
title_short Genetic markers of osteoarticular disorders: facts and hopes
title_sort genetic markers of osteoarticular disorders: facts and hopes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC128904/
https://www.ncbi.nlm.nih.gov/pubmed/11549368
http://dx.doi.org/10.1186/ar316
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