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Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value

The diagnosis of rheumatoid arthritis (RA) is primarily based on clinical symptoms, so it is often difficult to diagnose RA in very early stages of the disease. A disease-specific autoantibody that could be used as a serological marker would therefore be very useful. Most autoimmune diseases are cha...

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Autores principales: van Boekel, Martinus AM, Vossenaar, Erik R, van den Hoogen, Frank HJ, van Venrooij, Walther J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC128920/
https://www.ncbi.nlm.nih.gov/pubmed/11879544
http://dx.doi.org/10.1186/ar395
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author van Boekel, Martinus AM
Vossenaar, Erik R
van den Hoogen, Frank HJ
van Venrooij, Walther J
author_facet van Boekel, Martinus AM
Vossenaar, Erik R
van den Hoogen, Frank HJ
van Venrooij, Walther J
author_sort van Boekel, Martinus AM
collection PubMed
description The diagnosis of rheumatoid arthritis (RA) is primarily based on clinical symptoms, so it is often difficult to diagnose RA in very early stages of the disease. A disease-specific autoantibody that could be used as a serological marker would therefore be very useful. Most autoimmune diseases are characterized by a polyclonal B-cell response targeting multiple autoantigens. These immune responses are often not specific for a single disease. In this review, the most important autoantibody/autoantigen systems associated with RA are described and their utility as a diagnostic and prognostic tool, including their specificity, sensitivity and practical application, is discussed. We conclude that, at present, the antibody response directed to citrullinated antigens has the most valuable diagnostic and prognostic potential for RA.
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spelling pubmed-1289202002-10-28 Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value van Boekel, Martinus AM Vossenaar, Erik R van den Hoogen, Frank HJ van Venrooij, Walther J Arthritis Res Review The diagnosis of rheumatoid arthritis (RA) is primarily based on clinical symptoms, so it is often difficult to diagnose RA in very early stages of the disease. A disease-specific autoantibody that could be used as a serological marker would therefore be very useful. Most autoimmune diseases are characterized by a polyclonal B-cell response targeting multiple autoantigens. These immune responses are often not specific for a single disease. In this review, the most important autoantibody/autoantigen systems associated with RA are described and their utility as a diagnostic and prognostic tool, including their specificity, sensitivity and practical application, is discussed. We conclude that, at present, the antibody response directed to citrullinated antigens has the most valuable diagnostic and prognostic potential for RA. BioMed Central 2002 2001-11-06 /pmc/articles/PMC128920/ /pubmed/11879544 http://dx.doi.org/10.1186/ar395 Text en Copyright © 2001 BioMed Central Ltd
spellingShingle Review
van Boekel, Martinus AM
Vossenaar, Erik R
van den Hoogen, Frank HJ
van Venrooij, Walther J
Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value
title Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value
title_full Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value
title_fullStr Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value
title_full_unstemmed Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value
title_short Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value
title_sort autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC128920/
https://www.ncbi.nlm.nih.gov/pubmed/11879544
http://dx.doi.org/10.1186/ar395
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