Tumour necrosis factor-α stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-κB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b

Glucocorticoids have successfully been used in the treatment of rheumatoid arthritis. Data suggest that 7α-hydroxy-dehydroepiandrosterone (7α-OH-DHEA), an immunostimulating metabolite of dehydroepiandrosterone, can block glucocorticoid-induced immune suppression. Formation of 7α-OH-DHEA is catalyzed...

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Detalles Bibliográficos
Autores principales: Dulos, John, Kaptein, Allard, Kavelaars, Annemieke, Heijnen, Cobi, Boots, Annemieke
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1297571/
https://www.ncbi.nlm.nih.gov/pubmed/16277680
http://dx.doi.org/10.1186/ar1819

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1297571/
https://www.ncbi.nlm.nih.gov/pubmed/16277680
http://dx.doi.org/10.1186/ar1819

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