Open label phase II trial of single, ascending doses of MRA in Caucasian children with severe systemic juvenile idiopathic arthritis: proof of principle of the efficacy of IL-6 receptor blockade in this type of arthritis and demonstration of prolonged clinical improvement

Eighteen Caucasian (white, Middle East and Asian) children diagnosed by paediatric rheumatologists in the UK and France as having systemic juvenile idiopathic arthritis (sJIA) were enrolled in this open label, single dose trial. All patients had evidence of continued symptoms and disease activity fo...

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Detalles Bibliográficos
Autores principales: Woo, Patricia, Wilkinson, Nicholas, Prieur, Anne-Marie, Southwood, Taunton, Leone, Valentina, Livermore, Polly, Wythe, Helena, Thomson, David, Kishimoto, Tadamitsu
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1297576/
https://www.ncbi.nlm.nih.gov/pubmed/16277681
http://dx.doi.org/10.1186/ar1826

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