Structure-specific binding of MeCP2 to four-way junction DNA through its methyl CpG-binding domain

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MeCP2, whose methylated DNA-binding domain (MBD) binds preferentially to DNA containing 5Me-CpG relative to linear unmethylated DNA, also binds preferentially, and with similar affinity, to unmethylated four-way DNA junctions through the MBD. The Arg133Cys (R133C) mutation in the MBD, a Rett syndrom...

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Detalles Bibliográficos
Autores principales: Galvão, Teca Calcagno, Thomas, Jean O.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1298929/
https://www.ncbi.nlm.nih.gov/pubmed/16314321
http://dx.doi.org/10.1093/nar/gki971

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