Association of MHC and rheumatoid arthritis: HLA-DR4 and rheumatoid arthritis - studies in mice and men

Inherited susceptibility to rheumatoid arthritis (RA) is associated with the DRB1 genes encoding the human leukocyte antigen (HLA)-DR4 and HLA-DR1 molecules. Transgenic mice expressing these major histocompatibility complex (MHC) class II molecules have been developed to generate humanized models fo...

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Detalles Bibliográficos
Autores principales: Fugger , Lars, Svejgaard, Arne
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2000
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC130004/
https://www.ncbi.nlm.nih.gov/pubmed/11094431
http://dx.doi.org/10.1186/ar89
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author Fugger , Lars
Svejgaard, Arne
author_facet Fugger , Lars
Svejgaard, Arne
author_sort Fugger , Lars
collection PubMed
description Inherited susceptibility to rheumatoid arthritis (RA) is associated with the DRB1 genes encoding the human leukocyte antigen (HLA)-DR4 and HLA-DR1 molecules. Transgenic mice expressing these major histocompatibility complex (MHC) class II molecules have been developed to generate humanized models for RA. The relevance of these models for understanding RA will be discussed.
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spelling pubmed-1300042002-10-28 Association of MHC and rheumatoid arthritis: HLA-DR4 and rheumatoid arthritis - studies in mice and men Fugger , Lars Svejgaard, Arne Arthritis Res Review Inherited susceptibility to rheumatoid arthritis (RA) is associated with the DRB1 genes encoding the human leukocyte antigen (HLA)-DR4 and HLA-DR1 molecules. Transgenic mice expressing these major histocompatibility complex (MHC) class II molecules have been developed to generate humanized models for RA. The relevance of these models for understanding RA will be discussed. BioMed Central 2000 2000-04-25 /pmc/articles/PMC130004/ /pubmed/11094431 http://dx.doi.org/10.1186/ar89 Text en Copyright © 2000 Current Science Ltd
spellingShingle Review
Fugger , Lars
Svejgaard, Arne
Association of MHC and rheumatoid arthritis: HLA-DR4 and rheumatoid arthritis - studies in mice and men
title Association of MHC and rheumatoid arthritis: HLA-DR4 and rheumatoid arthritis - studies in mice and men
title_full Association of MHC and rheumatoid arthritis: HLA-DR4 and rheumatoid arthritis - studies in mice and men
title_fullStr Association of MHC and rheumatoid arthritis: HLA-DR4 and rheumatoid arthritis - studies in mice and men
title_full_unstemmed Association of MHC and rheumatoid arthritis: HLA-DR4 and rheumatoid arthritis - studies in mice and men
title_short Association of MHC and rheumatoid arthritis: HLA-DR4 and rheumatoid arthritis - studies in mice and men
title_sort association of mhc and rheumatoid arthritis: hla-dr4 and rheumatoid arthritis - studies in mice and men
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC130004/
https://www.ncbi.nlm.nih.gov/pubmed/11094431
http://dx.doi.org/10.1186/ar89
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