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Immune ablation and stem-cell therapy in autoimmune disease: Immunological reconstitution after high-dose immunosuppression and haematopoietic stem-cell transplantation
Studies on immunological reconstitution after immune ablation and stem-cell therapy may yield important clues to our understanding of the pathogenesis of human autoimmune disease, due to the profound effects of function and organization of the immune system. Such studies are also indispensable when...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2000
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC130008/ https://www.ncbi.nlm.nih.gov/pubmed/11094440 http://dx.doi.org/10.1186/ar101 |
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author | van Laar, Jacob M |
author_facet | van Laar, Jacob M |
author_sort | van Laar, Jacob M |
collection | PubMed |
description | Studies on immunological reconstitution after immune ablation and stem-cell therapy may yield important clues to our understanding of the pathogenesis of human autoimmune disease, due to the profound effects of function and organization of the immune system. Such studies are also indispensable when linking clinical sequelae such as opportunistic infections to the state of immune deficiency that ensues after the treatment. Much has been learnt on these issues from comparable studies in haemato-oncological diseases, although it remains to be proven that the data obtained from these studies can be extrapolated to rheumatological autoimmune diseases. Preliminary results from pilot studies in various rheumatological conditions not only pointed to clinical efficacy of the new treatment modality but also unveiled marked effects on T-cell receptor repertoires of circulating T lymphocytes, on titres of autoantibodies and T- and B-cell subsets. |
format | Text |
id | pubmed-130008 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2000 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-1300082002-10-28 Immune ablation and stem-cell therapy in autoimmune disease: Immunological reconstitution after high-dose immunosuppression and haematopoietic stem-cell transplantation van Laar, Jacob M Arthritis Res Review Studies on immunological reconstitution after immune ablation and stem-cell therapy may yield important clues to our understanding of the pathogenesis of human autoimmune disease, due to the profound effects of function and organization of the immune system. Such studies are also indispensable when linking clinical sequelae such as opportunistic infections to the state of immune deficiency that ensues after the treatment. Much has been learnt on these issues from comparable studies in haemato-oncological diseases, although it remains to be proven that the data obtained from these studies can be extrapolated to rheumatological autoimmune diseases. Preliminary results from pilot studies in various rheumatological conditions not only pointed to clinical efficacy of the new treatment modality but also unveiled marked effects on T-cell receptor repertoires of circulating T lymphocytes, on titres of autoantibodies and T- and B-cell subsets. BioMed Central 2000 2000-05-26 /pmc/articles/PMC130008/ /pubmed/11094440 http://dx.doi.org/10.1186/ar101 Text en Copyright © 2000 Current Science Ltd |
spellingShingle | Review van Laar, Jacob M Immune ablation and stem-cell therapy in autoimmune disease: Immunological reconstitution after high-dose immunosuppression and haematopoietic stem-cell transplantation |
title | Immune ablation and stem-cell therapy in autoimmune disease: Immunological reconstitution after high-dose immunosuppression and haematopoietic stem-cell transplantation |
title_full | Immune ablation and stem-cell therapy in autoimmune disease: Immunological reconstitution after high-dose immunosuppression and haematopoietic stem-cell transplantation |
title_fullStr | Immune ablation and stem-cell therapy in autoimmune disease: Immunological reconstitution after high-dose immunosuppression and haematopoietic stem-cell transplantation |
title_full_unstemmed | Immune ablation and stem-cell therapy in autoimmune disease: Immunological reconstitution after high-dose immunosuppression and haematopoietic stem-cell transplantation |
title_short | Immune ablation and stem-cell therapy in autoimmune disease: Immunological reconstitution after high-dose immunosuppression and haematopoietic stem-cell transplantation |
title_sort | immune ablation and stem-cell therapy in autoimmune disease: immunological reconstitution after high-dose immunosuppression and haematopoietic stem-cell transplantation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC130008/ https://www.ncbi.nlm.nih.gov/pubmed/11094440 http://dx.doi.org/10.1186/ar101 |
work_keys_str_mv | AT vanlaarjacobm immuneablationandstemcelltherapyinautoimmunediseaseimmunologicalreconstitutionafterhighdoseimmunosuppressionandhaematopoieticstemcelltransplantation |