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What you should know about PR3-ANCA: An introduction

Anti-neutrophil cytoplasmic antibodies (ANCA) have become important diagnostic markers of small vessel vasculitides characterized by focal necrotizing lesions of vessel walls and accumulation of lymphocytes and macrophages around the affected vessels. IgG class ANCA directed to proteinase 3 (PR3) of...

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Detalles Bibliográficos
Autor principal: Wiik, Allan
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2000
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC130013/
https://www.ncbi.nlm.nih.gov/pubmed/11094436
http://dx.doi.org/10.1186/ar96
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author Wiik, Allan
author_facet Wiik, Allan
author_sort Wiik, Allan
collection PubMed
description Anti-neutrophil cytoplasmic antibodies (ANCA) have become important diagnostic markers of small vessel vasculitides characterized by focal necrotizing lesions of vessel walls and accumulation of lymphocytes and macrophages around the affected vessels. IgG class ANCA directed to proteinase 3 (PR3) of neutrophils and monocytes seem to be directly involved in the pathophysiology of vascular damage by causing excessive neutrophil activation and vessel wall destruction. PR3 and elastase are important players in the mechanisms of vascular necrosis. Methods of detecting ANCA have now been defined but are not uniformly used, even though clinical decisions heavily depend on correct ANCA results.
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spelling pubmed-1300132002-10-28 What you should know about PR3-ANCA: An introduction Wiik, Allan Arthritis Res Review Anti-neutrophil cytoplasmic antibodies (ANCA) have become important diagnostic markers of small vessel vasculitides characterized by focal necrotizing lesions of vessel walls and accumulation of lymphocytes and macrophages around the affected vessels. IgG class ANCA directed to proteinase 3 (PR3) of neutrophils and monocytes seem to be directly involved in the pathophysiology of vascular damage by causing excessive neutrophil activation and vessel wall destruction. PR3 and elastase are important players in the mechanisms of vascular necrosis. Methods of detecting ANCA have now been defined but are not uniformly used, even though clinical decisions heavily depend on correct ANCA results. BioMed Central 2000 2000-06-12 /pmc/articles/PMC130013/ /pubmed/11094436 http://dx.doi.org/10.1186/ar96 Text en Copyright © 2000 Current Science Ltd
spellingShingle Review
Wiik, Allan
What you should know about PR3-ANCA: An introduction
title What you should know about PR3-ANCA: An introduction
title_full What you should know about PR3-ANCA: An introduction
title_fullStr What you should know about PR3-ANCA: An introduction
title_full_unstemmed What you should know about PR3-ANCA: An introduction
title_short What you should know about PR3-ANCA: An introduction
title_sort what you should know about pr3-anca: an introduction
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC130013/
https://www.ncbi.nlm.nih.gov/pubmed/11094436
http://dx.doi.org/10.1186/ar96
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