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What you should know about PR3-ANCA: An introduction
Anti-neutrophil cytoplasmic antibodies (ANCA) have become important diagnostic markers of small vessel vasculitides characterized by focal necrotizing lesions of vessel walls and accumulation of lymphocytes and macrophages around the affected vessels. IgG class ANCA directed to proteinase 3 (PR3) of...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2000
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC130013/ https://www.ncbi.nlm.nih.gov/pubmed/11094436 http://dx.doi.org/10.1186/ar96 |
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author | Wiik, Allan |
author_facet | Wiik, Allan |
author_sort | Wiik, Allan |
collection | PubMed |
description | Anti-neutrophil cytoplasmic antibodies (ANCA) have become important diagnostic markers of small vessel vasculitides characterized by focal necrotizing lesions of vessel walls and accumulation of lymphocytes and macrophages around the affected vessels. IgG class ANCA directed to proteinase 3 (PR3) of neutrophils and monocytes seem to be directly involved in the pathophysiology of vascular damage by causing excessive neutrophil activation and vessel wall destruction. PR3 and elastase are important players in the mechanisms of vascular necrosis. Methods of detecting ANCA have now been defined but are not uniformly used, even though clinical decisions heavily depend on correct ANCA results. |
format | Text |
id | pubmed-130013 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2000 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-1300132002-10-28 What you should know about PR3-ANCA: An introduction Wiik, Allan Arthritis Res Review Anti-neutrophil cytoplasmic antibodies (ANCA) have become important diagnostic markers of small vessel vasculitides characterized by focal necrotizing lesions of vessel walls and accumulation of lymphocytes and macrophages around the affected vessels. IgG class ANCA directed to proteinase 3 (PR3) of neutrophils and monocytes seem to be directly involved in the pathophysiology of vascular damage by causing excessive neutrophil activation and vessel wall destruction. PR3 and elastase are important players in the mechanisms of vascular necrosis. Methods of detecting ANCA have now been defined but are not uniformly used, even though clinical decisions heavily depend on correct ANCA results. BioMed Central 2000 2000-06-12 /pmc/articles/PMC130013/ /pubmed/11094436 http://dx.doi.org/10.1186/ar96 Text en Copyright © 2000 Current Science Ltd |
spellingShingle | Review Wiik, Allan What you should know about PR3-ANCA: An introduction |
title | What you should know about PR3-ANCA: An introduction |
title_full | What you should know about PR3-ANCA: An introduction |
title_fullStr | What you should know about PR3-ANCA: An introduction |
title_full_unstemmed | What you should know about PR3-ANCA: An introduction |
title_short | What you should know about PR3-ANCA: An introduction |
title_sort | what you should know about pr3-anca: an introduction |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC130013/ https://www.ncbi.nlm.nih.gov/pubmed/11094436 http://dx.doi.org/10.1186/ar96 |
work_keys_str_mv | AT wiikallan whatyoushouldknowaboutpr3ancaanintroduction |