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What you should know about PR3-ANCA: Conformational requirements of proteinase 3 (PR3) for enzymatic activity and recognition by PR3-ANCA
The neutrophil azurophil granule constituent proteinase 3 (PR3) is the principal antigen for anti-neutrophil cytoplasmic antibodies (ANCA) in Wegener's granulomatosis. The conformation of the mature PR3 enzyme results from intracellular post-translational processing. The nascent molecule underg...
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2000
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC130016/ https://www.ncbi.nlm.nih.gov/pubmed/11094439 http://dx.doi.org/10.1186/ar99 |