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Stage-specific changes in fetal thymocyte proliferation during the CD4(-)8(-) to CD4(+)8(+) transition in wild type, Rag1(-/-), and Hoxa3,Pax1 mutant mice
BACKGROUND: The function of the thymic microenvironment is to promote thymocyte maturation, in part via regulation of thymocyte proliferation and cell death. Defects in fetal thymic epithelial cell (TEC) development and function, and therefore in the formation of a functional microenvironment, can b...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2002
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC130029/ https://www.ncbi.nlm.nih.gov/pubmed/12241558 http://dx.doi.org/10.1186/1471-2172-3-12 |