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Association of circulating Chlamydia pneumoniae DNA with cardiovascular disease: a systematic review
BACKGROUND: Chlamydia pneumoniae antigens, nucleic acids, or intact organisms have been detected in human atheroma. However, the presence of antibody does not predict subsequent cardiovascular (CV) events. We performed a systematic review to determine whether the detection of C. pneumoniae DNA in pe...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2002
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC130041/ https://www.ncbi.nlm.nih.gov/pubmed/12359046 http://dx.doi.org/10.1186/1471-2334-2-21 |
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author | Smieja, Marek Mahony, James Petrich, Astrid Boman, Jens Chernesky, Max |
author_facet | Smieja, Marek Mahony, James Petrich, Astrid Boman, Jens Chernesky, Max |
author_sort | Smieja, Marek |
collection | PubMed |
description | BACKGROUND: Chlamydia pneumoniae antigens, nucleic acids, or intact organisms have been detected in human atheroma. However, the presence of antibody does not predict subsequent cardiovascular (CV) events. We performed a systematic review to determine whether the detection of C. pneumoniae DNA in peripheral blood mononuclear cells (PBMC) was associated with CV disease. METHODS: We sought studies of C. pneumoniae DNA detection in PBMC by polymerase chain reaction (PCR) among patients with CV disease or other clinical conditions. We pooled studies in which CV patients were compared with non-diseased controls. We analyzed differences between studies by meta-regression, to determine which epidemiological and technical characteristics were associated with higher prevalence. RESULTS: Eighteen relevant studies were identified. In nine CV studies with control subjects, the prevalence of circulating C. pneumoniae DNA was 252 of 1763 (14.3%) CV patients and 74 of 874 (8.5%) controls, for a pooled odds ratio of 2.03 (95% CI: 1.34, 3.08, P < 0.001). Prevalence was not adjusted for CV risk factors. Current smoking status, season, and age were associated with C. pneumoniae DNA detection. High prevalence (>40%) was found in patients with cardiac, vascular, chronic respiratory, or renal disease, and in blood donors. Substantial differences between studies were identified in methods of sampling, extraction, and PCR targets. CONCLUSIONS: C. pneumoniae DNA detection was associated with CV disease in unadjusted case-control studies. However, adjustment for potentially confounding measures such as smoking or season, and standardization of laboratory methods, are needed to confirm this association. |
format | Text |
id | pubmed-130041 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2002 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-1300412002-10-25 Association of circulating Chlamydia pneumoniae DNA with cardiovascular disease: a systematic review Smieja, Marek Mahony, James Petrich, Astrid Boman, Jens Chernesky, Max BMC Infect Dis Research Article BACKGROUND: Chlamydia pneumoniae antigens, nucleic acids, or intact organisms have been detected in human atheroma. However, the presence of antibody does not predict subsequent cardiovascular (CV) events. We performed a systematic review to determine whether the detection of C. pneumoniae DNA in peripheral blood mononuclear cells (PBMC) was associated with CV disease. METHODS: We sought studies of C. pneumoniae DNA detection in PBMC by polymerase chain reaction (PCR) among patients with CV disease or other clinical conditions. We pooled studies in which CV patients were compared with non-diseased controls. We analyzed differences between studies by meta-regression, to determine which epidemiological and technical characteristics were associated with higher prevalence. RESULTS: Eighteen relevant studies were identified. In nine CV studies with control subjects, the prevalence of circulating C. pneumoniae DNA was 252 of 1763 (14.3%) CV patients and 74 of 874 (8.5%) controls, for a pooled odds ratio of 2.03 (95% CI: 1.34, 3.08, P < 0.001). Prevalence was not adjusted for CV risk factors. Current smoking status, season, and age were associated with C. pneumoniae DNA detection. High prevalence (>40%) was found in patients with cardiac, vascular, chronic respiratory, or renal disease, and in blood donors. Substantial differences between studies were identified in methods of sampling, extraction, and PCR targets. CONCLUSIONS: C. pneumoniae DNA detection was associated with CV disease in unadjusted case-control studies. However, adjustment for potentially confounding measures such as smoking or season, and standardization of laboratory methods, are needed to confirm this association. BioMed Central 2002-10-01 /pmc/articles/PMC130041/ /pubmed/12359046 http://dx.doi.org/10.1186/1471-2334-2-21 Text en Copyright © 2002 Smieja et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. |
spellingShingle | Research Article Smieja, Marek Mahony, James Petrich, Astrid Boman, Jens Chernesky, Max Association of circulating Chlamydia pneumoniae DNA with cardiovascular disease: a systematic review |
title | Association of circulating Chlamydia pneumoniae DNA with cardiovascular disease: a systematic review |
title_full | Association of circulating Chlamydia pneumoniae DNA with cardiovascular disease: a systematic review |
title_fullStr | Association of circulating Chlamydia pneumoniae DNA with cardiovascular disease: a systematic review |
title_full_unstemmed | Association of circulating Chlamydia pneumoniae DNA with cardiovascular disease: a systematic review |
title_short | Association of circulating Chlamydia pneumoniae DNA with cardiovascular disease: a systematic review |
title_sort | association of circulating chlamydia pneumoniae dna with cardiovascular disease: a systematic review |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC130041/ https://www.ncbi.nlm.nih.gov/pubmed/12359046 http://dx.doi.org/10.1186/1471-2334-2-21 |
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