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Association of circulating Chlamydia pneumoniae DNA with cardiovascular disease: a systematic review

BACKGROUND: Chlamydia pneumoniae antigens, nucleic acids, or intact organisms have been detected in human atheroma. However, the presence of antibody does not predict subsequent cardiovascular (CV) events. We performed a systematic review to determine whether the detection of C. pneumoniae DNA in pe...

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Autores principales: Smieja, Marek, Mahony, James, Petrich, Astrid, Boman, Jens, Chernesky, Max
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC130041/
https://www.ncbi.nlm.nih.gov/pubmed/12359046
http://dx.doi.org/10.1186/1471-2334-2-21
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author Smieja, Marek
Mahony, James
Petrich, Astrid
Boman, Jens
Chernesky, Max
author_facet Smieja, Marek
Mahony, James
Petrich, Astrid
Boman, Jens
Chernesky, Max
author_sort Smieja, Marek
collection PubMed
description BACKGROUND: Chlamydia pneumoniae antigens, nucleic acids, or intact organisms have been detected in human atheroma. However, the presence of antibody does not predict subsequent cardiovascular (CV) events. We performed a systematic review to determine whether the detection of C. pneumoniae DNA in peripheral blood mononuclear cells (PBMC) was associated with CV disease. METHODS: We sought studies of C. pneumoniae DNA detection in PBMC by polymerase chain reaction (PCR) among patients with CV disease or other clinical conditions. We pooled studies in which CV patients were compared with non-diseased controls. We analyzed differences between studies by meta-regression, to determine which epidemiological and technical characteristics were associated with higher prevalence. RESULTS: Eighteen relevant studies were identified. In nine CV studies with control subjects, the prevalence of circulating C. pneumoniae DNA was 252 of 1763 (14.3%) CV patients and 74 of 874 (8.5%) controls, for a pooled odds ratio of 2.03 (95% CI: 1.34, 3.08, P < 0.001). Prevalence was not adjusted for CV risk factors. Current smoking status, season, and age were associated with C. pneumoniae DNA detection. High prevalence (>40%) was found in patients with cardiac, vascular, chronic respiratory, or renal disease, and in blood donors. Substantial differences between studies were identified in methods of sampling, extraction, and PCR targets. CONCLUSIONS: C. pneumoniae DNA detection was associated with CV disease in unadjusted case-control studies. However, adjustment for potentially confounding measures such as smoking or season, and standardization of laboratory methods, are needed to confirm this association.
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spelling pubmed-1300412002-10-25 Association of circulating Chlamydia pneumoniae DNA with cardiovascular disease: a systematic review Smieja, Marek Mahony, James Petrich, Astrid Boman, Jens Chernesky, Max BMC Infect Dis Research Article BACKGROUND: Chlamydia pneumoniae antigens, nucleic acids, or intact organisms have been detected in human atheroma. However, the presence of antibody does not predict subsequent cardiovascular (CV) events. We performed a systematic review to determine whether the detection of C. pneumoniae DNA in peripheral blood mononuclear cells (PBMC) was associated with CV disease. METHODS: We sought studies of C. pneumoniae DNA detection in PBMC by polymerase chain reaction (PCR) among patients with CV disease or other clinical conditions. We pooled studies in which CV patients were compared with non-diseased controls. We analyzed differences between studies by meta-regression, to determine which epidemiological and technical characteristics were associated with higher prevalence. RESULTS: Eighteen relevant studies were identified. In nine CV studies with control subjects, the prevalence of circulating C. pneumoniae DNA was 252 of 1763 (14.3%) CV patients and 74 of 874 (8.5%) controls, for a pooled odds ratio of 2.03 (95% CI: 1.34, 3.08, P < 0.001). Prevalence was not adjusted for CV risk factors. Current smoking status, season, and age were associated with C. pneumoniae DNA detection. High prevalence (>40%) was found in patients with cardiac, vascular, chronic respiratory, or renal disease, and in blood donors. Substantial differences between studies were identified in methods of sampling, extraction, and PCR targets. CONCLUSIONS: C. pneumoniae DNA detection was associated with CV disease in unadjusted case-control studies. However, adjustment for potentially confounding measures such as smoking or season, and standardization of laboratory methods, are needed to confirm this association. BioMed Central 2002-10-01 /pmc/articles/PMC130041/ /pubmed/12359046 http://dx.doi.org/10.1186/1471-2334-2-21 Text en Copyright © 2002 Smieja et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
spellingShingle Research Article
Smieja, Marek
Mahony, James
Petrich, Astrid
Boman, Jens
Chernesky, Max
Association of circulating Chlamydia pneumoniae DNA with cardiovascular disease: a systematic review
title Association of circulating Chlamydia pneumoniae DNA with cardiovascular disease: a systematic review
title_full Association of circulating Chlamydia pneumoniae DNA with cardiovascular disease: a systematic review
title_fullStr Association of circulating Chlamydia pneumoniae DNA with cardiovascular disease: a systematic review
title_full_unstemmed Association of circulating Chlamydia pneumoniae DNA with cardiovascular disease: a systematic review
title_short Association of circulating Chlamydia pneumoniae DNA with cardiovascular disease: a systematic review
title_sort association of circulating chlamydia pneumoniae dna with cardiovascular disease: a systematic review
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC130041/
https://www.ncbi.nlm.nih.gov/pubmed/12359046
http://dx.doi.org/10.1186/1471-2334-2-21
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