Pharmacological basis for the therapy of pain and inflammation with nonsteroidal anti-inflammatory drugs

Nonsteroidal anti-inflammatory drugs (NSAIDs) belong to the most frequently used drugs. The discovery of an inducible isoform of cyclo-oxygenase (COX-2) has led to an intensive worldwide search and the introduction of selective COX-2 inhibitors. In this review, recent advances in understanding the m...

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Detalles Bibliográficos
Autor principal: Steinmeyer, Jürgen
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2000
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC130140/
https://www.ncbi.nlm.nih.gov/pubmed/11094452
http://dx.doi.org/10.1186/ar116
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author Steinmeyer, Jürgen
author_facet Steinmeyer, Jürgen
author_sort Steinmeyer, Jürgen
collection PubMed
description Nonsteroidal anti-inflammatory drugs (NSAIDs) belong to the most frequently used drugs. The discovery of an inducible isoform of cyclo-oxygenase (COX-2) has led to an intensive worldwide search and the introduction of selective COX-2 inhibitors. In this review, recent advances in understanding the mechanism of action of NSAIDs and, in this context, clinical findings on NSAID-induced gastrointestinal side effects are summarized. This knowledge is important for the effective treatment of pain and inflammation, as well as for preventing serious and sometimes lethal gastrointestinal side effects.
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spelling pubmed-1301402002-10-31 Pharmacological basis for the therapy of pain and inflammation with nonsteroidal anti-inflammatory drugs Steinmeyer, Jürgen Arthritis Res Review Nonsteroidal anti-inflammatory drugs (NSAIDs) belong to the most frequently used drugs. The discovery of an inducible isoform of cyclo-oxygenase (COX-2) has led to an intensive worldwide search and the introduction of selective COX-2 inhibitors. In this review, recent advances in understanding the mechanism of action of NSAIDs and, in this context, clinical findings on NSAID-induced gastrointestinal side effects are summarized. This knowledge is important for the effective treatment of pain and inflammation, as well as for preventing serious and sometimes lethal gastrointestinal side effects. BioMed Central 2000 2000-07-20 /pmc/articles/PMC130140/ /pubmed/11094452 http://dx.doi.org/10.1186/ar116 Text en Copyright © 2000 Current Science Ltd
spellingShingle Review
Steinmeyer, Jürgen
Pharmacological basis for the therapy of pain and inflammation with nonsteroidal anti-inflammatory drugs
title Pharmacological basis for the therapy of pain and inflammation with nonsteroidal anti-inflammatory drugs
title_full Pharmacological basis for the therapy of pain and inflammation with nonsteroidal anti-inflammatory drugs
title_fullStr Pharmacological basis for the therapy of pain and inflammation with nonsteroidal anti-inflammatory drugs
title_full_unstemmed Pharmacological basis for the therapy of pain and inflammation with nonsteroidal anti-inflammatory drugs
title_short Pharmacological basis for the therapy of pain and inflammation with nonsteroidal anti-inflammatory drugs
title_sort pharmacological basis for the therapy of pain and inflammation with nonsteroidal anti-inflammatory drugs
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC130140/
https://www.ncbi.nlm.nih.gov/pubmed/11094452
http://dx.doi.org/10.1186/ar116
work_keys_str_mv AT steinmeyerjurgen pharmacologicalbasisforthetherapyofpainandinflammationwithnonsteroidalantiinflammatorydrugs

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