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The interaction site of Flap Endonuclease-1 with WRN helicase suggests a coordination of WRN and PCNA

Werner and Bloom syndromes are genetic RecQ helicase disorders characterized by genomic instability. Biochemical and genetic data indicate that an important protein interaction of WRN and Bloom syndrome (BLM) helicases is with the structure-specific nuclease Flap Endonuclease 1 (FEN-1), an enzyme th...

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Detalles Bibliográficos
Autores principales:	Sharma, Sudha, Sommers, Joshua A., Gary, Ronald K., Friedrich-Heineken, Erica, Hübscher, Ulrich, Brosh, Robert M.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2005
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1301591/ https://www.ncbi.nlm.nih.gov/pubmed/16326861 http://dx.doi.org/10.1093/nar/gki1002

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