Aggregation and retention of human urokinase type plasminogen activator in the yeast endoplasmic reticulum

BACKGROUND: Secretion of recombinant proteins in yeast can be affected by their improper folding in the endoplasmic reticulum and subsequent elimination of the misfolded molecules via the endoplasmic reticulum associated protein degradation pathway. Recombinant proteins can also be degraded by the v...

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Detalles Bibliográficos
Autores principales: Agaphonov, Michael O, Romanova, Nina V, Trushkina, Polina M, Smirnov, Vladimir N, Ter-Avanesyan, Michael D
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC130179/
https://www.ncbi.nlm.nih.gov/pubmed/12366865
http://dx.doi.org/10.1186/1471-2199-3-15

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