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Short report: autistic gastrointestinal and eating symptoms treated with secretin: a subtype of autism

Pervasive Developmental Disorders (PDD) are chronic, lifelong disorders for which there is as yet no effective cure, and medical management remains a challenge for clinicians. The current report describes two patients affected by autistic disorder with associated gastrointestinal symptoms. They rece...

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Autores principales: Pallanti, Stefano, Lassi, Stefano, La Malfa, Giampaolo, Campigli, Marco, Di Rubbo, Roberto, Paolini, Giulia, Cesarali, Valentina
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1308834/
https://www.ncbi.nlm.nih.gov/pubmed/16287506
http://dx.doi.org/10.1186/1745-0179-1-24
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author Pallanti, Stefano
Lassi, Stefano
La Malfa, Giampaolo
Campigli, Marco
Di Rubbo, Roberto
Paolini, Giulia
Cesarali, Valentina
author_facet Pallanti, Stefano
Lassi, Stefano
La Malfa, Giampaolo
Campigli, Marco
Di Rubbo, Roberto
Paolini, Giulia
Cesarali, Valentina
author_sort Pallanti, Stefano
collection PubMed
description Pervasive Developmental Disorders (PDD) are chronic, lifelong disorders for which there is as yet no effective cure, and medical management remains a challenge for clinicians. The current report describes two patients affected by autistic disorder with associated gastrointestinal symptoms. They received multiple doses of intravenous secretin for a six-month period and were assessed with several specific outcome measures to evaluate drug effect. The administration of secretin led to some significant and lasting improvement in only one case. Gastroesophageal reflux may contribute to some of the behavioural problems and explain the effect of secretin since its suppressive effect on gastric secretion is well known. It is also true that autistic children with gastroesophageal reflux and a higher IQ could constitute a subtype which responds to secretin administration and that could be labelled as a "gastrointestinal subtype".
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spelling pubmed-13088342005-12-08 Short report: autistic gastrointestinal and eating symptoms treated with secretin: a subtype of autism Pallanti, Stefano Lassi, Stefano La Malfa, Giampaolo Campigli, Marco Di Rubbo, Roberto Paolini, Giulia Cesarali, Valentina Clin Pract Epidemiol Ment Health Short report Pervasive Developmental Disorders (PDD) are chronic, lifelong disorders for which there is as yet no effective cure, and medical management remains a challenge for clinicians. The current report describes two patients affected by autistic disorder with associated gastrointestinal symptoms. They received multiple doses of intravenous secretin for a six-month period and were assessed with several specific outcome measures to evaluate drug effect. The administration of secretin led to some significant and lasting improvement in only one case. Gastroesophageal reflux may contribute to some of the behavioural problems and explain the effect of secretin since its suppressive effect on gastric secretion is well known. It is also true that autistic children with gastroesophageal reflux and a higher IQ could constitute a subtype which responds to secretin administration and that could be labelled as a "gastrointestinal subtype". BioMed Central 2005-11-15 /pmc/articles/PMC1308834/ /pubmed/16287506 http://dx.doi.org/10.1186/1745-0179-1-24 Text en Copyright ©2005 Pallanti et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short report
Pallanti, Stefano
Lassi, Stefano
La Malfa, Giampaolo
Campigli, Marco
Di Rubbo, Roberto
Paolini, Giulia
Cesarali, Valentina
Short report: autistic gastrointestinal and eating symptoms treated with secretin: a subtype of autism
title Short report: autistic gastrointestinal and eating symptoms treated with secretin: a subtype of autism
title_full Short report: autistic gastrointestinal and eating symptoms treated with secretin: a subtype of autism
title_fullStr Short report: autistic gastrointestinal and eating symptoms treated with secretin: a subtype of autism
title_full_unstemmed Short report: autistic gastrointestinal and eating symptoms treated with secretin: a subtype of autism
title_short Short report: autistic gastrointestinal and eating symptoms treated with secretin: a subtype of autism
title_sort short report: autistic gastrointestinal and eating symptoms treated with secretin: a subtype of autism
topic Short report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1308834/
https://www.ncbi.nlm.nih.gov/pubmed/16287506
http://dx.doi.org/10.1186/1745-0179-1-24
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