Cargando…
Choosing an appropriate bacterial typing technique for epidemiologic studies
A wide variety of bacterial typing systems are currently in use that vary greatly with respect to the effort required, cost, reliability and ability to discriminate between bacterial strains. No one technique is optimal for all forms of investigation. We discuss the desired level of discrimination a...
Autores principales: | , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2005
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1308839/ https://www.ncbi.nlm.nih.gov/pubmed/16309556 http://dx.doi.org/10.1186/1742-5573-2-10 |
_version_ | 1782126291516915712 |
---|---|
author | Foxman, Betsy Zhang, Lixin Koopman, James S Manning, Shannon D Marrs, Carl F |
author_facet | Foxman, Betsy Zhang, Lixin Koopman, James S Manning, Shannon D Marrs, Carl F |
author_sort | Foxman, Betsy |
collection | PubMed |
description | A wide variety of bacterial typing systems are currently in use that vary greatly with respect to the effort required, cost, reliability and ability to discriminate between bacterial strains. No one technique is optimal for all forms of investigation. We discuss the desired level of discrimination and need for a biologic basis for grouping strains of apparently different types when using bacterial typing techniques for different epidemiologic applications: 1) confirming epidemiologic linkage in outbreak investigations, 2) generating hypotheses about epidemiologic relationships between bacterial strains in the absence of epidemiologic information, and 3) describing the distributions of bacterial types and identifying determinants of those distributions. Inferences made from molecular epidemiologic studies of bacteria depend upon both the typing technique selected and the study design used; thus, choice of typing technique is pivotal for increasing our understanding of the pathogenesis and transmission, and eventual disease prevention. |
format | Text |
id | pubmed-1308839 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-13088392005-12-08 Choosing an appropriate bacterial typing technique for epidemiologic studies Foxman, Betsy Zhang, Lixin Koopman, James S Manning, Shannon D Marrs, Carl F Epidemiol Perspect Innov Analytic Perspective A wide variety of bacterial typing systems are currently in use that vary greatly with respect to the effort required, cost, reliability and ability to discriminate between bacterial strains. No one technique is optimal for all forms of investigation. We discuss the desired level of discrimination and need for a biologic basis for grouping strains of apparently different types when using bacterial typing techniques for different epidemiologic applications: 1) confirming epidemiologic linkage in outbreak investigations, 2) generating hypotheses about epidemiologic relationships between bacterial strains in the absence of epidemiologic information, and 3) describing the distributions of bacterial types and identifying determinants of those distributions. Inferences made from molecular epidemiologic studies of bacteria depend upon both the typing technique selected and the study design used; thus, choice of typing technique is pivotal for increasing our understanding of the pathogenesis and transmission, and eventual disease prevention. BioMed Central 2005-11-25 /pmc/articles/PMC1308839/ /pubmed/16309556 http://dx.doi.org/10.1186/1742-5573-2-10 Text en Copyright © 2005 Foxman et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Analytic Perspective Foxman, Betsy Zhang, Lixin Koopman, James S Manning, Shannon D Marrs, Carl F Choosing an appropriate bacterial typing technique for epidemiologic studies |
title | Choosing an appropriate bacterial typing technique for epidemiologic studies |
title_full | Choosing an appropriate bacterial typing technique for epidemiologic studies |
title_fullStr | Choosing an appropriate bacterial typing technique for epidemiologic studies |
title_full_unstemmed | Choosing an appropriate bacterial typing technique for epidemiologic studies |
title_short | Choosing an appropriate bacterial typing technique for epidemiologic studies |
title_sort | choosing an appropriate bacterial typing technique for epidemiologic studies |
topic | Analytic Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1308839/ https://www.ncbi.nlm.nih.gov/pubmed/16309556 http://dx.doi.org/10.1186/1742-5573-2-10 |
work_keys_str_mv | AT foxmanbetsy choosinganappropriatebacterialtypingtechniqueforepidemiologicstudies AT zhanglixin choosinganappropriatebacterialtypingtechniqueforepidemiologicstudies AT koopmanjamess choosinganappropriatebacterialtypingtechniqueforepidemiologicstudies AT manningshannond choosinganappropriatebacterialtypingtechniqueforepidemiologicstudies AT marrscarlf choosinganappropriatebacterialtypingtechniqueforepidemiologicstudies |