Maximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer's disease

Neuronal expression of cyclooxygenase-2 (COX-2) and cell cycle proteins is suggested to contribute to neurodegeneration during Alzheimer's disease (AD). The stimulus that induces COX-2 and cell cycle protein expression in AD is still elusive. Activated glia cells are shown to secrete substances...

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Detalles Bibliográficos
Autores principales: Hoozemans, Jeroen JM, van Haastert, Elise S, Veerhuis, Robert, Arendt, Thomas, Scheper, Wiep, Eikelenboom, Piet, Rozemuller, Annemieke JM
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1308853/
https://www.ncbi.nlm.nih.gov/pubmed/16300681
http://dx.doi.org/10.1186/1742-2094-2-27

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