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Proximity to Pollution Sources and Risk of Amphibian Limb Malformation
The cause of limb deformities in wild amphibian populations remains unclear, even though the apparent increase in prevalence of this condition may have implications for human health. Few studies have simultaneously assessed the effect of multiple exposures on the risk of limb deformities. In a cross...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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National Institute of Environmental Health Sciences
2005
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1310909/ https://www.ncbi.nlm.nih.gov/pubmed/16263502 http://dx.doi.org/10.1289/ehp.7585 |
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author | Taylor, Brynn Skelly, David Demarchis, Livia K. Slade, Martin D. Galusha, Deron Rabinowitz, Peter M. |
author_facet | Taylor, Brynn Skelly, David Demarchis, Livia K. Slade, Martin D. Galusha, Deron Rabinowitz, Peter M. |
author_sort | Taylor, Brynn |
collection | PubMed |
description | The cause of limb deformities in wild amphibian populations remains unclear, even though the apparent increase in prevalence of this condition may have implications for human health. Few studies have simultaneously assessed the effect of multiple exposures on the risk of limb deformities. In a cross-sectional survey of 5,264 hylid and ranid metamorphs in 42 Vermont wetlands, we assessed independent risk factors for nontraumatic limb malformation. The rate of nontraumatic limb malformation varied by location from 0 to 10.2%. Analysis of a subsample did not demonstrate any evidence of infection with the parasite Ribeiroia. We used geographic information system (GIS) land-use/land-cover data to validate field observations of land use in the proximity of study wetlands. In a multiple logistic regression model that included land use as well as developmental stage, genus, and water-quality measures, proximity to agricultural land use was associated with an increased risk of limb malformation (odds ratio = 2.26; 95% confidence interval, 1.42–3.58; p < 0.001). The overall discriminant power of the statistical model was high (C = 0.79). These findings from one of the largest systematic surveys to date provide support for the role of chemical toxicants in the development of amphibian limb malformation and demonstrate the value of an epidemiologic approach to this problem. |
format | Text |
id | pubmed-1310909 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | National Institute of Environmental Health Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-13109092005-12-12 Proximity to Pollution Sources and Risk of Amphibian Limb Malformation Taylor, Brynn Skelly, David Demarchis, Livia K. Slade, Martin D. Galusha, Deron Rabinowitz, Peter M. Environ Health Perspect Research The cause of limb deformities in wild amphibian populations remains unclear, even though the apparent increase in prevalence of this condition may have implications for human health. Few studies have simultaneously assessed the effect of multiple exposures on the risk of limb deformities. In a cross-sectional survey of 5,264 hylid and ranid metamorphs in 42 Vermont wetlands, we assessed independent risk factors for nontraumatic limb malformation. The rate of nontraumatic limb malformation varied by location from 0 to 10.2%. Analysis of a subsample did not demonstrate any evidence of infection with the parasite Ribeiroia. We used geographic information system (GIS) land-use/land-cover data to validate field observations of land use in the proximity of study wetlands. In a multiple logistic regression model that included land use as well as developmental stage, genus, and water-quality measures, proximity to agricultural land use was associated with an increased risk of limb malformation (odds ratio = 2.26; 95% confidence interval, 1.42–3.58; p < 0.001). The overall discriminant power of the statistical model was high (C = 0.79). These findings from one of the largest systematic surveys to date provide support for the role of chemical toxicants in the development of amphibian limb malformation and demonstrate the value of an epidemiologic approach to this problem. National Institute of Environmental Health Sciences 2005-11 2005-07-11 /pmc/articles/PMC1310909/ /pubmed/16263502 http://dx.doi.org/10.1289/ehp.7585 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
spellingShingle | Research Taylor, Brynn Skelly, David Demarchis, Livia K. Slade, Martin D. Galusha, Deron Rabinowitz, Peter M. Proximity to Pollution Sources and Risk of Amphibian Limb Malformation |
title | Proximity to Pollution Sources and Risk of Amphibian Limb Malformation |
title_full | Proximity to Pollution Sources and Risk of Amphibian Limb Malformation |
title_fullStr | Proximity to Pollution Sources and Risk of Amphibian Limb Malformation |
title_full_unstemmed | Proximity to Pollution Sources and Risk of Amphibian Limb Malformation |
title_short | Proximity to Pollution Sources and Risk of Amphibian Limb Malformation |
title_sort | proximity to pollution sources and risk of amphibian limb malformation |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1310909/ https://www.ncbi.nlm.nih.gov/pubmed/16263502 http://dx.doi.org/10.1289/ehp.7585 |
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