Comparison of the Use of a Physiologically Based Pharmacokinetic Model and a Classical Pharmacokinetic Model for Dioxin Exposure Assessments

In epidemiologic studies, exposure assessments of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) assume a fixed elimination rate. Recent data suggest a dose-dependent elimination rate for TCDD. A physiologically based pharmacokinetic (PBPK) model, which uses a body-burden–dependent elimination rate, was...

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Detalles Bibliográficos
Autores principales: Emond, Claude, Michalek, Joel E., Birnbaum, Linda S., DeVito, Michael J.
Formato: Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2005
Materias:
Commentaries & Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1314902/
https://www.ncbi.nlm.nih.gov/pubmed/16330344
http://dx.doi.org/10.1289/ehp.8016

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