Cargando…
Organophosphate Urinary Metabolite Levels during Pregnancy and after Delivery in Women Living in an Agricultural Community
Little information has been published about pesticide exposures experienced by pregnant women. We measured six dialkyl phosphate (DAP) urinary metabolites of organophosphate (OP) pesticides in 600 pregnant, low-income women living in the Salinas Valley, California, an agricultural area. A total of 2...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
National Institute of Environmental Health Sciences
2005
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1314925/ https://www.ncbi.nlm.nih.gov/pubmed/16330368 http://dx.doi.org/10.1289/ehp.7894 |
_version_ | 1782126362396459008 |
---|---|
author | Bradman, Asa Eskenazi, Brenda Barr, Dana B. Bravo, Roberto Castorina, Rosemary Chevrier, Jonathan Kogut, Katherine Harnly, Martha E. McKone, Thomas E. |
author_facet | Bradman, Asa Eskenazi, Brenda Barr, Dana B. Bravo, Roberto Castorina, Rosemary Chevrier, Jonathan Kogut, Katherine Harnly, Martha E. McKone, Thomas E. |
author_sort | Bradman, Asa |
collection | PubMed |
description | Little information has been published about pesticide exposures experienced by pregnant women. We measured six dialkyl phosphate (DAP) urinary metabolites of organophosphate (OP) pesticides in 600 pregnant, low-income women living in the Salinas Valley, California, an agricultural area. A total of 28% were employed as farm fieldworkers during pregnancy, and 81% had at least one household member who worked in agriculture. Samples were collected twice during pregnancy (mean = 13 and 26 weeks’ gestation, respectively) and just after delivery (mean = 9 days). As in other studies, dimethyldithiophosphate levels were higher than those of other urinary OP metabolites. Total DAP metabolite levels in samples collected after delivery were higher than in samples collected during pregnancy. Median metabolite levels at the first and second prenatal sampling points and at the postpartum collection were 102.8, 106.8, and 227.2 nmol/L, respectively. Both prenatal and postpartum metabolite levels were higher in these Salinas Valley women than in a sample of women of childbearing age in the general U.S. population (National Health and Nutrition Examination Survey), although the deviation from U.S. reference levels was most pronounced after delivery. Higher DAP metabolite levels in the immediate postpartum period may have implications for estimating dose during pregnancy and for exposure during lactation. |
format | Text |
id | pubmed-1314925 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | National Institute of Environmental Health Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-13149252006-01-02 Organophosphate Urinary Metabolite Levels during Pregnancy and after Delivery in Women Living in an Agricultural Community Bradman, Asa Eskenazi, Brenda Barr, Dana B. Bravo, Roberto Castorina, Rosemary Chevrier, Jonathan Kogut, Katherine Harnly, Martha E. McKone, Thomas E. Environ Health Perspect Research Little information has been published about pesticide exposures experienced by pregnant women. We measured six dialkyl phosphate (DAP) urinary metabolites of organophosphate (OP) pesticides in 600 pregnant, low-income women living in the Salinas Valley, California, an agricultural area. A total of 28% were employed as farm fieldworkers during pregnancy, and 81% had at least one household member who worked in agriculture. Samples were collected twice during pregnancy (mean = 13 and 26 weeks’ gestation, respectively) and just after delivery (mean = 9 days). As in other studies, dimethyldithiophosphate levels were higher than those of other urinary OP metabolites. Total DAP metabolite levels in samples collected after delivery were higher than in samples collected during pregnancy. Median metabolite levels at the first and second prenatal sampling points and at the postpartum collection were 102.8, 106.8, and 227.2 nmol/L, respectively. Both prenatal and postpartum metabolite levels were higher in these Salinas Valley women than in a sample of women of childbearing age in the general U.S. population (National Health and Nutrition Examination Survey), although the deviation from U.S. reference levels was most pronounced after delivery. Higher DAP metabolite levels in the immediate postpartum period may have implications for estimating dose during pregnancy and for exposure during lactation. National Institute of Environmental Health Sciences 2005-12 2005-07-18 /pmc/articles/PMC1314925/ /pubmed/16330368 http://dx.doi.org/10.1289/ehp.7894 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
spellingShingle | Research Bradman, Asa Eskenazi, Brenda Barr, Dana B. Bravo, Roberto Castorina, Rosemary Chevrier, Jonathan Kogut, Katherine Harnly, Martha E. McKone, Thomas E. Organophosphate Urinary Metabolite Levels during Pregnancy and after Delivery in Women Living in an Agricultural Community |
title | Organophosphate Urinary Metabolite Levels during Pregnancy and after Delivery in Women Living in an Agricultural Community |
title_full | Organophosphate Urinary Metabolite Levels during Pregnancy and after Delivery in Women Living in an Agricultural Community |
title_fullStr | Organophosphate Urinary Metabolite Levels during Pregnancy and after Delivery in Women Living in an Agricultural Community |
title_full_unstemmed | Organophosphate Urinary Metabolite Levels during Pregnancy and after Delivery in Women Living in an Agricultural Community |
title_short | Organophosphate Urinary Metabolite Levels during Pregnancy and after Delivery in Women Living in an Agricultural Community |
title_sort | organophosphate urinary metabolite levels during pregnancy and after delivery in women living in an agricultural community |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1314925/ https://www.ncbi.nlm.nih.gov/pubmed/16330368 http://dx.doi.org/10.1289/ehp.7894 |
work_keys_str_mv | AT bradmanasa organophosphateurinarymetabolitelevelsduringpregnancyandafterdeliveryinwomenlivinginanagriculturalcommunity AT eskenazibrenda organophosphateurinarymetabolitelevelsduringpregnancyandafterdeliveryinwomenlivinginanagriculturalcommunity AT barrdanab organophosphateurinarymetabolitelevelsduringpregnancyandafterdeliveryinwomenlivinginanagriculturalcommunity AT bravoroberto organophosphateurinarymetabolitelevelsduringpregnancyandafterdeliveryinwomenlivinginanagriculturalcommunity AT castorinarosemary organophosphateurinarymetabolitelevelsduringpregnancyandafterdeliveryinwomenlivinginanagriculturalcommunity AT chevrierjonathan organophosphateurinarymetabolitelevelsduringpregnancyandafterdeliveryinwomenlivinginanagriculturalcommunity AT kogutkatherine organophosphateurinarymetabolitelevelsduringpregnancyandafterdeliveryinwomenlivinginanagriculturalcommunity AT harnlymarthae organophosphateurinarymetabolitelevelsduringpregnancyandafterdeliveryinwomenlivinginanagriculturalcommunity AT mckonethomase organophosphateurinarymetabolitelevelsduringpregnancyandafterdeliveryinwomenlivinginanagriculturalcommunity |